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  1. Content type: Methodology article

    The reduction of tetrazolium salts by NAD(P)H to formazan product has been widely used to determine the metabolic activity of cells, and as an indicator of cell viability. However, the application of a WST-8 b...

    Authors: Kamonwan Chamchoy, Danaya Pakotiprapha, Pornpan Pumirat, Ubolsree Leartsakulpanich and Usa Boonyuen

    Citation: BMC Biochemistry 2019 20:4

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  2. Content type: Research article

    Genetic factors affect the risk of non-alcoholic fatty liver disease (NAFLD) and colorectal adenoma (CRA) importantly. Transmembrane protein 6 superfamily member 2 (TM6SF2) rs58542926 is a significant genetic ...

    Authors: Yuan Li, Shousheng Liu, Yuqiang Gao, Huan Ma, Shuhui Zhan, Yan Yang, Yongning Xin and Shiying Xuan

    Citation: BMC Biochemistry 2019 20:3

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  3. Content type: Research article

    Many bacteria and certain eukaryotes utilize multi-step His-to-Asp phosphorelays for adaptive responses to their extracellular environments. Histidine phosphotransfer (HPt) proteins function as key components ...

    Authors: Emily N. Kennedy, Skyler D. Hebdon, Smita K. Menon, Clay A. Foster, Daniel M. Copeland, Qingping Xu, Fabiola Janiak-Spens and Ann H. West

    Citation: BMC Biochemistry 2019 20:1

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  4. Content type: Research article

    Sepsis is a severe condition characterised by the body’s systemic inflammatory response to infection. The specific sepsis-related biomarkers should be used in clinical diagnosis, therapeutic response monitorin...

    Authors: Yanqiang Hou, Dongyu Liang, Yang Liu, Hongwei Chen and Xiaoli Lou

    Citation: BMC Biochemistry 2018 19:13

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  5. Content type: Methodology article

    Studying proteins and enzymes involved in important biological processes in the Aedes aegypti mosquito is limited by the quantity that can be directly isolated from the mosquito. Adding to this difficulty, digest...

    Authors: James T. Nguyen, Jonathan Fong, Daniel Fong, Timothy Fong, Rachael M. Lucero, Jamie M. Gallimore, Olive E. Burata, Kamille Parungao and Alberto A. Rascón Jr

    Citation: BMC Biochemistry 2018 19:12

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  6. Content type: Research article

    Islet amyloid polypeptide (IAPP) or amylin deposits can be found in the islets of type 2 diabetes patients. The peptide is suggested to be involved in the etiology of the disease through formation of amyloid d...

    Authors: Samaneh Miraee-Nedjad, Paul F. G. Sims, Jean-Marc Schwartz and Andrew J. Doig

    Citation: BMC Biochemistry 2018 19:9

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  7. Content type: Research article

    Stilbene cleaving oxygenases (SCOs), also known as lignostilbene-α,β-dioxygenases (LSDs) mediate the oxidative cleavage of the olefinic double bonds of lignin-derived intermediate phenolic stilbenes, yielding ...

    Authors: Peter C. Loewen, Jacek Switala, James P. Wells, Fang Huang, Anthony T. Zara, John S. Allingham and Michele C. Loewen

    Citation: BMC Biochemistry 2018 19:8

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  8. Content type: Research article

    Endonucleases play critical roles in maintaining genomic stability and regulating cell growth. The purpose of this study was to evaluate detection of endonuclease activity as an indicator in the early diagnosi...

    Authors: Renquan Lu, Yingchao Wang, Xiaofeng Xu, Suhong Xie, Yanchun Wang, Ailing Zhong, Hui Zheng, Yiwen Yu, Xiang Gao and Lin Guo

    Citation: BMC Biochemistry 2018 19:6

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  9. Content type: Research article

    In this study Aesculus indica fruit was subjected to isolation of phytochemicals. Two antioxidants quercetin and Mandelic acid were isolated in pure state. The free radical scavenging and acetyl choline esterase ...

    Authors: Muhammad Zahoor, Sadaf Shafiq, Habib Ullah, Abdul Sadiq and Farhat Ullah

    Citation: BMC Biochemistry 2018 19:5

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  10. Content type: Research article

    Corynebacterium urealyticum, a pathogenic, multidrug resistant member of the mycolata, is known as causative agent of urinary tract infections although it is a bacterium of the skin flora. This pathogenic bacteri...

    Authors: Narges Abdali, Farhan Younas, Samaneh Mafakheri, Karunakar R. Pothula, Ulrich Kleinekathöfer, Andreas Tauch and Roland Benz

    Citation: BMC Biochemistry 2018 19:3

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  11. Content type: Research article

    An important step in human immunodeficiency virus type 1 (HIV-1) replication is the packaging of tRNA3Lys from the host cell, which plays the role of primer RNA in the process of initiation of reverse transcripti...

    Authors: Fawzi Khoder-Agha, José M. Dias, Martine Comisso and Marc Mirande

    Citation: BMC Biochemistry 2018 19:2

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  12. Content type: Research article

    Enzymes display high reactivity and selectivity under natural conditions, but may suffer from decreased efficiency in industrial applications. A strategy to address this limitation is to immobilize the enzyme....

    Authors: Cyrielle Bonzom, Laura Schild, Hanna Gustafsson and Lisbeth Olsson

    Citation: BMC Biochemistry 2018 19:1

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  13. Content type: Research article

    Despite of the presence of sulfhydryl oxidases (SOXs) in the secretomes of industrially relevant organisms and their many potential applications, only few of these enzymes have been biochemically characterized...

    Authors: Outi Nivala, Greta Faccio, Mikko Arvas, Perttu Permi, Johanna Buchert, Kristiina Kruus and Maija-Liisa Mattinen

    Citation: BMC Biochemistry 2017 18:15

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  14. Content type: Research article

    Peptides with cytoprotective functions, including antioxidants and anti-infectives, could be useful therapeutics. Carnosine, β-alanine-histidine, is a dipeptide with anti-oxidant properties. Tripeptides of Ala...

    Authors: Hideki Shimura, Ryota Tanaka, Yoshiaki Shimada, Kazuo Yamashiro, Nobutaka Hattori and Takao Urabe

    Citation: BMC Biochemistry 2017 18:14

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  15. Content type: Research article

    Antiproliferative factor (APF) is a sialoglycopeptide elevated in the urine of patients with interstitial cystitis—a chronic, painful bladder disease. APF inhibits the proliferation of normal bladder epithelia...

    Authors: Burzin Chavda, Jun Ling, Thomas Majernick and Sonia Lobo Planey

    Citation: BMC Biochemistry 2017 18:13

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  16. Content type: Methodology article

    Luciferases, enzymes that catalyze bioluminescent reactions in different organisms, have been extensively used for bioanalytical purposes. The most well studied bioluminescent system is that of firefly and oth...

    Authors: Arina Marina Perez, Bruno Aquino, Vadim Viviani and Jörg Kobarg

    Citation: BMC Biochemistry 2017 18:12

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  17. Content type: Research article

    Mice were bitten by five-pace vipers (Deinagkistrodon acutus), and then envenomed. It was well-known that the snake venom mainly disturbed the blood homeostasis of the envenomed victims. Ocassionally, we found th...

    Authors: Bin Zhou, Gang Liu, Qiyi He, Bo Li and Xiaodong Yu

    Citation: BMC Biochemistry 2017 18:11

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  18. Content type: Research article

    Protein tyrosine phosphatases (PTPs) like dual specificity phosphatase 5 (DUSP5) and protein tyrosine phosphatase 1B (PTP1B) are drug targets for diseases that include cancer, diabetes, and vascular disorders ...

    Authors: Robert D. Bongard, Michael Lepley, Khushabu Thakur, Marat R. Talipov, Jaladhi Nayak, Rachel A. Jones Lipinski, Chris Bohl, Noreena Sweeney, Ramani Ramchandran, Rajendra Rathore and Daniel S. Sem

    Citation: BMC Biochemistry 2017 18:10

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  19. Content type: Research article

    The marine invertebrate starfish was found to contain a novel α-N-acetylgalactosaminidase, α-GalNAcase II, which catalyzes removal of terminal α-N-acetylgalactosamine (α-GalNAc), in addition to a typical α-N-a...

    Authors: Md. Harun-Or Rashid, Golam Sadik, AHM Khurshid Alam and Toshihisa Tanaka

    Citation: BMC Biochemistry 2017 18:9

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  20. Content type: Research article

    The carbapenem subclass of β-lactams is among the most potent antibiotics available today. Emerging evidence shows that, unlike other subclasses of β-lactams, carbapenems bind to and inhibit non-classical tran...

    Authors: Mario A. Bianchet, Ying H. Pan, Leighanne A. Brammer Basta, Harry Saavedra, Evan P. Lloyd, Pankaj Kumar, Rohini Mattoo, Craig A. Townsend and Gyanu Lamichhane

    Citation: BMC Biochemistry 2017 18:8

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  21. Content type: Research article

    Eukaryotic tRNA splicing is an essential process in the transformation of a primary tRNA transcript into a mature functional tRNA molecule. 5′-phosphate ligation involves two steps: a healing reaction catalyze...

    Authors: Gopinath Muruganandam, Arne Raasakka, Matti Myllykoski, Inari Kursula and Petri Kursula

    Citation: BMC Biochemistry 2017 18:7

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  22. Content type: Research article

    The smoothelin-like 1 protein (SMTNL1) can associate with tropomyosin (Tpm) and calmodulin (CaM), two proteins essential to the smooth muscle contractile process. SMTNL1 is phosphorylated at Ser301 by protein ...

    Authors: Annegret Ulke-Lemée, David Hao Sun, Hiroaki Ishida, Hans J. Vogel and Justin A. MacDonald

    Citation: BMC Biochemistry 2017 18:5

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  23. Content type: Research article

    β-Glucosidase is claimed as a key enzyme in cellulose hydrolysis. The cellulosic fibers are usually entrapped with hemicelluloses containing xylose. So there is ongoing interest in searching for glucose- and x...

    Authors: Yang Liu, Rui Li, Jing Wang, Xiaohan Zhang, Rong Jia, Yi Gao and Hui Peng

    Citation: BMC Biochemistry 2017 18:4

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  24. Content type: Research article

    Histatins are histidine rich polypeptides produced in the parotid and submandibular gland and secreted into the saliva. Histatin-3 and −5 are the most important polycationic histatins. They possess antimicrobi...

    Authors: Edna Blotnick, Asaf Sol, Gilad Bachrach and Andras Muhlrad

    Citation: BMC Biochemistry 2017 18:3

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  25. Content type: Research article

    In vertebrates, there is an intimate relationship between copper and iron homeostasis. Copper deficiency, which leads to a defect in ceruloplasmin enzymatic activity, has a strong effect on iron homeostasis re...

    Authors: Luca Marco Di Bella, Roberto Alampi, Flavia Biundo, Giovanni Toscano and Maria Rosa Felice

    Citation: BMC Biochemistry 2017 18:1

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  26. Content type: Research article

    There are 11 variants of linker histone H1 in mammalian cells. Beyond their shared abilities to stabilize and condense chromatin, the H1 variants have been found to have non-redundant functions, the mechanisms...

    Authors: Pei Zhang, Owen E. Branson, Michael A. Freitas and Mark R. Parthun

    Citation: BMC Biochemistry 2016 17:18

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  27. Content type: Research article

    Human tyrosine-protein phosphatase non-receptor type substrate 1α (SIRPA) is a surface marker identified in cardiomyocytes differentiated from human embryonic stem cells. Our objective was to determine if circ...

    Authors: Pranali Patel, Uros Kuzmanov and Seema Mital

    Citation: BMC Biochemistry 2016 17:17

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  28. Content type: Research article

    Beta-galactosidase (EC, a commercially important enzyme, catalyses the hydrolysis of β-1,3- and β-1,4-galactosyl bonds of polymer or oligosaccharidesas well as transglycosylation of β-galactopyranosi...

    Authors: Thao Thi Nguyen, Hanh Van Vu, Nhung Thi Hong Nguyen, Tuyen Thi Do and Thanh Sy Le Nguyen

    Citation: BMC Biochemistry 2016 17:15

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  29. Content type: Research article

    The mechanistic target of rapamycin complex 1 (mTORC1) is a well-conserved serine/threonine protein kinase that controls autophagy as well as many other processes such as protein synthesis, cell growth, and me...

    Authors: Hongjie Pan, Xiao-ping Zhong and Sunhee Lee

    Citation: BMC Biochemistry 2016 17:14

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  30. Content type: Research article

    Intermolecular autophosphorylation at Tyr416 is a conserved mechanism of activation among the members of the Src family of nonreceptor tyrosine kinases. Like several other tyrosine kinases, Src can catalyze th...

    Authors: M. Zulema Cabail, Emily I. Chen, Antonius Koller and W. Todd Miller

    Citation: BMC Biochemistry 2016 17:13

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  31. Content type: Research article

    Nucleoside triphosphate (NTP) hydrolysis is a key reaction in biology. It involves breaking two very stable bonds (one P–O bond and one O–H bond of water), in either a concurrent or a sequential way. Here, we ...

    Authors: Farooq Ahmad Kiani and Stefan Fischer

    Citation: BMC Biochemistry 2016 17:12

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  32. Content type: Research article

    Protein kinase C δ (PKCδ) is known to be an important regulator of apoptosis, having mainly pro- but also anti-apoptotic effects depending on context. In a previous study, we found that PKCδ interacts with the...

    Authors: Christian Holmgren, Louise Cornmark, Gry Kalstad Lønne, Katarzyna Chmielarska Masoumi and Christer Larsson

    Citation: BMC Biochemistry 2016 17:11

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  33. Content type: Research article

    Human phospholipid scramblase 1 (hPLSCR1) was initially identified as a Ca2+ dependent phospholipid translocator involved in disrupting membrane asymmetry. Recent reports revealed that hPLSCR1 acts as a multifunc...

    Authors: Ulaganathan Sivagnanam, Shweta Narayana Murthy and Sathyanarayana N. Gummadi

    Citation: BMC Biochemistry 2016 17:10

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  34. Content type: Research article

    In drug discovery research, cell-based phenotypic screening is an essential method for obtaining potential drug candidates. Revealing the mechanism of action is a key step on the path to drug discovery. Howeve...

    Authors: Yasunori Fukuda, Osamu Sano, Kenichi Kazetani, Koji Yamamoto, Hidehisa Iwata and Junji Matsui

    Citation: BMC Biochemistry 2016 17:9

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  35. Content type: Research article

    Dnmt3a is a DNA methyltransferase that establishes de novo DNA methylation in mammals. The structure of the Dnmt3a C-terminal domain is similar to the bacterial M. HhaI enzyme, a well-studied prokaryotic DNA meth...

    Authors: Olga V. Lukashevich, Natalia A. Cherepanova, Renata Z. Jurkovska, Albert Jeltsch and Elizaveta S. Gromova

    Citation: BMC Biochemistry 2016 17:7

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  36. Content type: Research article

    Thauera linaloolentis 47Lol uses the tertiary monoterpene alcohol (R,S)-linalool as sole carbon and energy source under denitrifying conditions. The conversion of linalool to geraniol ...

    Authors: Robert Marmulla, Barbara Šafarić, Stephanie Markert, Thomas Schweder and Jens Harder

    Citation: BMC Biochemistry 2016 17:6

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  37. Content type: Research article

    1,2-Dichlorobenzene (1,2-DCB) is a benzene-derived molecule with two Cl atoms that is commonly utilized in the synthesis of pesticides. 1,2-DCB can be absorbed by living creatures and its effects on naturally-...

    Authors: Javier Vargas-Medrano, Jorge A. Sierra-Fonseca and Luis F. Plenge-Tellechea

    Citation: BMC Biochemistry 2016 17:5

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2017 Journal Metrics

  • Citation Impact
    1.595 - 2-year Impact Factor
    1.515 - 5-year Impact Factor
    0.503 - Source Normalized Impact per Paper (SNIP)
    0.708 - SCImago Journal Rank (SJR)


    Social Media Impact
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