BMC Biochemistry

Featured article: An evolutionary encounter between tRNA and myelin maturation

tRNA splicing is an essential process in the maturation of eukaryotic pre-tRNA molecules. This study shows that tRNA healing enzymes from yeast and lancelet share structural and functional properties with members of the 2H-phosphoesterase superfamily, in particular the vertebrate myelin enzyme CNPase. While domain organization has been conserved, functions of the individual domains may have been altered or lost during evolution.

The conserved residues of Dnmt3a, R200 and R202, are essential for methylation activity. They are involved in positioning of the flipped target base and in creating and stabilizing of the transient covalent intermediate of the methylation reaction.

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Aims and scope

BMC Biochemistry is an open access, peer-reviewed journal that considers articles on all aspects of biochemical processes, including the structure, function and dynamics of metabolic pathways, supramolecular complexes, enzymes, proteins, nucleic acids and small molecular components of organelles, cells and tissues.

Editor

Alison Cuff, BioMed Central

Section Editors

Sabato D'Auria, CNR
Chris Grant, University of Manchester
Albert Jeltsch, Universität Stuttgart
Joel Weiner, University of Alberta

Albert Jeltsch, Section Editor

Prof. Jeltsch is professor of Biochemistry at the University Stuttgart. His research group is leading in the biochemical study of bacterial DNA methyltransferases and mammalian DNA methyltransferases. Their work has been published in more than 200 papers. Prof. Jeltsch joined the board of BMC Biochemistry in 2009.

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Behind the Image: a bug’s life

Published on: 15 September 2017
Socio-economic disadvantage and cancer survival disparities

Published on: 14 September 2017
The Martian had a lot of problems. Anemia probably wasn’t one of them.

Published on: 12 September 2017

Featured article: An evolutionary encounter between tRNA and myelin maturation

Featured article: Essential residues of Dnmt3a

Articles

Antiproliferative factor (APF) binds specifically to sites within the cytoskeleton-associated protein 4 (CKAP4) extracellular domain

Use of a special Brazilian red-light emitting railroad worm Luciferase in bioassays of NEK7 protein Kinase and Creatine Kinase

Dacin, one metalloproteinase from Deinagkistrodon acutus venom inhibiting contraction of mouse ileum muscle

Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor

Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase Ldt_Mt2 by biapenem and tebipenem

Determination of carbohydrate-deficient transferrin in a Han Chinese population

Expression and characterization of a β-fructofuranosidase from the parasitic protist Trichomonas vaginalis

Soybean peroxidase-mediated degradation of an azo dye– a detailed mechanistic study

Digested wheat gluten inhibits binding between leptin and its receptor

A simplified method for analysis of polyunsaturated fatty acids

Aims and scope

Editor

Section Editors

Albert Jeltsch, Section Editor

BMC Series blog

Behind the Image: a bug’s life

Socio-economic disadvantage and cancer survival disparities

The Martian had a lot of problems. Anemia probably wasn’t one of them.

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