Featured article: An evolutionary encounter between tRNA and myelin maturation

tRNA splicing is an essential process in the maturation of eukaryotic pre-tRNA molecules. This study shows that tRNA healing enzymes from yeast and lancelet share structural and functional properties with members of the 2H-phosphoesterase superfamily, in particular the vertebrate myelin enzyme CNPase. While domain organization has been conserved, functions of the individual domains may have been altered or lost during evolution.

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Aims and scope

BMC Biochemistry is an open access, peer-reviewed journal that considers articles on all aspects of biochemical processes, including the structure, function and dynamics of metabolic pathways, supramolecular complexes, enzymes, proteins, nucleic acids and small molecular components of organelles, cells and tissues.


Section Editors

  • Sabato D'Auria, CNR
  • Chris Grant, University of Manchester
  • Albert Jeltsch, Universität Stuttgart
  • Joel Weiner, University of Alberta