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  1. The use of metagenomics in enzyme discovery constitutes a powerful approach to access to genomes of unculturable community of microorganisms and isolate novel valuable biocatalysts for use in a wide range of b...

    Authors: Concetta De Santi, Bjørn Altermark, Marcin Miroslaw Pierechod, Luca Ambrosino, Donatella de Pascale and Nils-Peder Willassen

    Citation: BMC Biochemistry 2016 17:1

    Content type: Research article

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  2. Destabilase-Lysozyme (mlDL) is a multifunctional i-type enzyme that has been found in the secretions from the salivary glands of medicinal leeches. mlDL has been shown to exhibit isopeptidase, muramidase and a...

    Authors: Alexey S. Kurdyumov, Valentin A. Manuvera, Isolda P. Baskova and Vassili N. Lazarev

    Citation: BMC Biochemistry 2015 16:27

    Content type: Research article

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  3. β-Mannans are abundant and diverse plant structural and storage polysaccharides. Certain human gut microbiota members including health-promoting Bifidobacterium spp. catabolize dietary mannans. Little insight is ...

    Authors: Johan Morrill, Evelina Kulcinskaja, Anna Maria Sulewska, Sampo Lahtinen, Henrik Stålbrand, Birte Svensson and Maher Abou Hachem

    Citation: BMC Biochemistry 2015 16:26

    Content type: Research article

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  4. eIF3f is a multifunctional protein capable of interacting with proteins involved in different cellular processes, such as protein synthesis, DNA repair, and viral mRNA edition. In human cells, eIF3f is related...

    Authors: Mario Javier Gutiérrez-Fernández, Ana Edith Higareda-Mendoza, César Adrián Gómez-Correa and Marco Aurelio Pardo-Galván

    Citation: BMC Biochemistry 2015 16:25

    Content type: Research article

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  5. The defensive capacities of plant protease Inhibitors (PI) rely on inhibition of proteases in insect guts or those secreted by microorganisms; and also prevent uncontrolled proteolysis and offer protection aga...

    Authors: V D Sirisha Gandreddi, Vijaya Rachel Kappala, Kunal Zaveri and Kiranmayi Patnala

    Citation: BMC Biochemistry 2015 16:23

    Content type: Research article

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  6. Aberrant mitochondrial function, including excessive reactive oxygen species (ROS) production, has been implicated in the pathogenesis of human diseases. The use of mitochondrial inhibitors to ascertain the si...

    Authors: Aaron M. Gusdon, Gabriel A. Fernandez-Bueno, Stephanie Wohlgemuth, Jenelle Fernandez, Jing Chen and Clayton E. Mathews

    Citation: BMC Biochemistry 2015 16:22

    Content type: Research article

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  7. Members of Rhizopus species are the most common cause of mucormycosis, a rare but often fatal fungal infection. Host induced pathogen apoptosis and pathogen induced host cell apoptosis are often involved in funga...

    Authors: Manoj Saxena, Rohit Kumar Sharma, Josell Ramirez-Paz, Arthur D. Tinoco and Kai Griebenow

    Citation: BMC Biochemistry 2015 16:21

    Content type: Research article

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    The Erratum to this article has been published in BMC Biochemistry 2016 17:3

  8. Saccharomyces cerevisiae triosephosphate isomerase (yTIM) is a dimeric protein that shows noncoincident unfolding and refolding transitions (hysteresis) in temperature scans, a phenome...

    Authors: Ariana Labastida-Polito, Georgina Garza-Ramos, Menandro Camarillo-Cadena, Rafael A. Zubillaga and Andrés Hernández-Arana

    Citation: BMC Biochemistry 2015 16:20

    Content type: Research article

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  9. Dual-specificity phosphatase-5 (DUSP5) plays a central role in vascular development and disease. We present a p-nitrophenol phosphate (pNPP) based enzymatic assay to screen for inhibitors of the phosphatase domai...

    Authors: Terrence S. Neumann, Elise A. Span, Kelsey S. Kalous, Robert Bongard, Adam Gastonguay, Michael A. Lepley, Raman G. Kutty, Jaladhi Nayak, Chris Bohl, Rachel G. Lange, Majher I. Sarker, Marat R. Talipov, Rajendra Rathore, Ramani Ramchandran and Daniel S. Sem

    Citation: BMC Biochemistry 2015 16:19

    Content type: Research article

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  10. Computational protein design is a rapidly maturing field within structural biology, with the goal of designing proteins with custom structures and functions. Such proteins could find widespread medical and ind...

    Authors: Deepesh Nagarajan, Geeta Deka and Megha Rao

    Citation: BMC Biochemistry 2015 16:18

    Content type: Research article

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  11. Green fluorescent protein (GFP) and its derivative fluorescent proteins (FPs) are among the most commonly used reporter systems for studying gene expression and protein interaction in biomedical research. Most...

    Authors: Shu-su Liu, Xuan Wei, Xue Dong, Liang Xu, Jia Liu and Biao Jiang

    Citation: BMC Biochemistry 2015 16:17

    Content type: Research article

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  12. Potassium channels play a fundamental role in resetting the resting membrane potential of excitable cells. Determining the intracellular trafficking and localization mechanisms of potassium channels provides a...

    Authors: John M. Spear, Dolly Al Koborssy, Austin B. Schwartz, Adam J. Johnson, Anjon Audhya, Debra A. Fadool and Scott M. Stagg

    Citation: BMC Biochemistry 2015 16:16

    Content type: Research article

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  13. The 5′-triphosphorylated, 2′-5′-linked oligoadenylate polyribonucleotides (2-5As) are central to the interferon-induced antiviral 2-5A system. The 2-5As bind and activate the RNase L, an endoRNase degrading vi...

    Authors: Jesper Buchhave Poulsen, Karina Hansen Kjær, Just Justesen and Pia Møller Martensen

    Citation: BMC Biochemistry 2015 16:15

    Content type: Methodology article

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  14. The activity of eukaryotic DNA polymerase delta (Pol δ) plays an essential role in genome stability through its effects on DNA replication and repair. The p125 catalytic subunit of Pol δ is encoded by POLD1 gene ...

    Authors: Jing Song, Ping Hong, Chengeng Liu, Yueqi Zhang, Jinling Wang and Peichang Wang

    Citation: BMC Biochemistry 2015 16:14

    Content type: Research article

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  15. To investigate the roles of androgen receptor (AR) in epithelial- mesenchymal transition (EMT) in human prostate cancer stem progenitor (S/P) cells isolated from LNCaP cell line.

    Authors: Ma Zhifang, Wei Liang, Zhang Wei, Hao Bin, Tu Rui, Wu Nan and Zhang Shuhai

    Citation: BMC Biochemistry 2015 16:13

    Content type: Research article

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  16. Fidelity of DNA polymerases can be influenced by cation co-factors. Physiologically, Mg2+ is used as a co-factor by HIV reverse transcriptase (RT) to perform catalysis; however, alternative cations including Mn2+

    Authors: Vasudevan Achuthan and Jeffrey J DeStefano

    Citation: BMC Biochemistry 2015 16:12

    Content type: Research article

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  17. Quercetinases are metal-dependent dioxygenases of the cupin superfamily. While fungal quercetinases are copper proteins, recombinant Streptomyces quercetinase (QueD) was previously described to be capable of inco...

    Authors: Dimitrios Nianios, Sven Thierbach, Lenz Steimer, Pavel Lulchev, Dagmar Klostermeier and Susanne Fetzner

    Citation: BMC Biochemistry 2015 16:10

    Content type: Research article

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  18. Gentiana rhodantha, a rich source of iridoids and polyphenols, is a traditional ethnomedicine widely used in China. Metabolic fingerprinting based on a LC-UV-MS/MS method was applied to explore...

    Authors: Yu Pan, Ji Zhang, Tao Shen, Yan-Li Zhao, Yuan-Zhong Wang and Wan-Yi Li

    Citation: BMC Biochemistry 2015 16:9

    Content type: Methodology article

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  19. The protein growth arrest specific-1 (GAS1) was discovered based on its ability to stop the cell cycle. During development it is involved in embryonic patterning, inhibits cell proliferation and mediates cell ...

    Authors: Katja Rosti, Adrian Goldman and Tommi Kajander

    Citation: BMC Biochemistry 2015 16:8

    Content type: Research article

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  20. Calmodulin (CaM) plays an important role in Ca2+-dependent signal transduction. Ca2+ binding to CaM triggers a conformational change, forming a hydrophobic patch that is important for target protein recognition. ...

    Authors: Drake Jensen, Nicole Reynolds, Ya-Ping Yang, Shubha Shakya, Zhi-Qiang Wang, Dennis J Stuehr and Chin-Chuan Wei

    Citation: BMC Biochemistry 2015 16:6

    Content type: Research article

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  21. Baculoviruses are widely used for the production of recombinant proteins, biopesticides and as gene delivery systems. One of the viral forms called polyhedra has been recently exploited as a scaffold system to...

    Authors: Alicia Sampieri, Agustín Luz-Madrigal, Jesus Zepeda and Luis Vaca

    Citation: BMC Biochemistry 2015 16:5

    Content type: Research article

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  22. Par14, a member of the parvulin family of peptidyl-prolyl cis-trans isomerases that is involved in rRNA processing, microtubule formation and the glucose metabolism and has been suggested to play a role in chroma...

    Authors: Akuma D Saningong and Peter Bayer

    Citation: BMC Biochemistry 2015 16:4

    Content type: Research article

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  23. Leptin resistance is considered a primary risk factor for obesity. It has been hypothesized that dietary cereal grain protein could cause leptin resistance by preventing leptin from binding to its receptor. No...

    Authors: Tommy Jönsson, Ashfaque A Memon, Kristina Sundquist, Jan Sundquist, Stefan Olsson, Amarnadh Nalla, Mikael Bauer and Sara Linse

    Citation: BMC Biochemistry 2015 16:3

    Content type: Research article

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  24. Histone deacetylase inhibitors (HDACi’s) are emerging as promising anticancer drugs alone or in combination with chemotherapy or radiotherapy agents. Previous research suggests that HDACi’s have a high degree ...

    Authors: Liping Li, Youxiang Sun, Jiangqin Liu, Xiaodan Wu, Lijun Chen, Li Ma and Pengfei Wu

    Citation: BMC Biochemistry 2015 16:2

    Content type: Research article

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  25. Mesenchymal stem cells (MSCs) can differentiate into chondroblasts, adipocytes, or osteoblasts under appropriate stimulation. Mechano-growth factor (MGF) reportedly displays a neuroprotective effect in cerebra...

    Authors: Yanxiang Tong, Wei Feng, Yimin Wu, Huicheng Lv, Yanfei Jia and Dianming Jiang

    Citation: BMC Biochemistry 2015 16:1

    Content type: Research article

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  26. The Arabidopsis thaliana protein atTic20 is a key component of the protein import machinery at the inner envelope membrane of chloroplasts. As a component of the TIC complex, it is believed to form a preprotein-c...

    Authors: James H Campbell, Tuan Hoang, Masoud Jelokhani-Niaraki and Matthew D Smith

    Citation: BMC Biochemistry 2014 15:29

    Content type: Research article

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  27. A shift between two dimer conformations has been proposed for the transcription factor STAT1 (signal transducer and activator of transcription 1) which links DNA binding of the parallel dimer to tyrosine dephosph...

    Authors: Theresa Riebeling, Julia Staab, Christoph Herrmann-Lingen and Thomas Meyer

    Citation: BMC Biochemistry 2014 15:28

    Content type: Research article

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  28. The mitogen-activated protein kinases (MAPKs) pathway is critical for cellular signaling, and proteins such as phosphatases that regulate this pathway are important for normal tissue development. Based on our ...

    Authors: Jaladhi Nayak, Adam J Gastonguay, Marat R Talipov, Padmanabhan Vakeel, Elise A Span, Kelsey S Kalous, Raman G Kutty, Davin R Jensen, Phani Raj Pokkuluri, Daniel S Sem, Rajendra Rathore and Ramani Ramchandran

    Citation: BMC Biochemistry 2014 15:27

    Content type: Research article

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  29. Staphyloccocal nuclease domain-containing protein 1 (SND1) is involved in the regulation of gene expression and RNA protection. While numerous studies have established that SND1 protein expression is modulated...

    Authors: Sandra Armengol, Enara Arretxe, Leire Enzunza, Sarai Mula, Begoña Ochoa, Yolanda Chico and María José Martínez

    Citation: BMC Biochemistry 2014 15:25

    Content type: Research article

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  30. Neuronal differentiation is largely under the control of basic Helix-Loop-Helix (bHLH) proneural transcription factors that play key roles during development of the embryonic nervous system. In addition to wel...

    Authors: Gary S McDowell, Christopher J Hindley, Guy Lippens, Isabelle Landrieu and Anna Philpott

    Citation: BMC Biochemistry 2014 15:24

    Content type: Research article

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  31. Hydroxyl radical that has the highest reactivity among reactive oxygen species (ROS) is generated through l-tyrosine-tyrosinase reaction. Thus, the melanogenesis might induce oxidative stress in the skin. A rbuti...

    Authors: Mika Tada, Masahiro Kohno and Yoshimi Niwano

    Citation: BMC Biochemistry 2014 15:23

    Content type: Research article

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  32. Ethylene is one of the most used chemical monomers derived from non-renewable sources and we are investigating the possibility of producing it in yeast via the ethylene forming enzyme (EFE) from Pseudomonas syrin...

    Authors: Nina Johansson, Karl O Persson, Christer Larsson and Joakim Norbeck

    Citation: BMC Biochemistry 2014 15:22

    Content type: Research article

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  33. Previous screening of the substrate repertoires and substrate specificity profiles of granzymes resulted in long substrate lists highly likely containing bystander substrates. Here, a recently developed degrad...

    Authors: Petra Van Damme, Kim Plasman, Giel Vandemoortele, Veronique Jonckheere, Sebastian Maurer-Stroh and Kris Gevaert

    Citation: BMC Biochemistry 2014 15:21

    Content type: Research article

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  34. Dioscorea is a genus of flowering plants, and some Dioscorea species are known and used as a source for the steroidal sapogenin diosgenin. To screen potential resource from Dioscorea species and related medicinal...

    Authors: Tao Yi, Lan-Lan Fan, Hong-Li Chen, Guo-Yuan Zhu, Hau-Man Suen, Yi-Na Tang, Lin Zhu, Chu Chu, Zhong-Zhen Zhao and Hu-Biao Chen

    Citation: BMC Biochemistry 2014 15:19

    Content type: Research article

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  35. The cosmetics market has rapidly increased over the last years. For example, in 2011 it reached 242.8 billion US dollars, which was a 3.9% increase compared to 2010. There have been many recent trials aimed at...

    Authors: Dae-Hun Park, Dae Hyun Jung, Soo Jung Kim, Sung Han Kim and Kyung Mok Park

    Citation: BMC Biochemistry 2014 15:18

    Content type: Research article

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  36. Human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomesase, is responsible for telomere maintenance and its reactivation is implicated in almost 90% human cancers. Recent evidences sho...

    Authors: Xu Cao, Chiou Mee Kong, Kanchi Madhu Mathi, Yoon Pin Lim, Valere Cacheux-Rataboul and Xueying Wang

    Citation: BMC Biochemistry 2014 15:17

    Content type: Research article

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  37. Cytochrome c (Cyt c) is an apoptosis-initiating protein when released into the cytoplasm of eukaryotic cells and therefore a possible cancer drug candidate. Although proteins have been increasingly important a...

    Authors: Yamixa Delgado, Moraima Morales-Cruz, José Hernández-Román, Yashira Martínez and Kai Griebenow

    Citation: BMC Biochemistry 2014 15:16

    Content type: Research article

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  38. Urease, one of the highly efficient known enzymes, catalyzes the hydrolysis of urea into ammonia and carbon dioxide. The present study aimed to extract urease from pea seeds (Pisum Sativum L). The enzyme was then...

    Authors: Mohamed E EL-Hefnawy, Mohamed Sakran, Ali I Ismail and Eman Fahmy Aboelfetoh

    Citation: BMC Biochemistry 2014 15:15

    Content type: Research article

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  39. Secreted luciferases are highly useful bioluminescent reporters for cell-based assays and drug discovery. A variety of secreted luciferases from marine organisms have been described that harbor an N-terminal s...

    Authors: Christin Luft, Jamie Freeman, David Elliott, Nadia Al-Tamimi, Janos Kriston-Vizi, Jacob Heintze, Ida Lindenschmidt, Brian Seed and Robin Ketteler

    Citation: BMC Biochemistry 2014 15:14

    Content type: Methodology article

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  40. During EGFR internalization CIN85 bridges EGFR-Cbl complex, endocytic machinery and fusible membrane through the interactions of CIN85 with c-Cbl, endophilins and phosphatidic acid. These protein-protein and p...

    Authors: Xiudan Zheng, Jing Zhang and Kan Liao

    Citation: BMC Biochemistry 2014 15:13

    Content type: Research article

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  41. Trichomonas vaginalis, a flagellated protozoan, is the agent responsible for trichomoniasis, the most common nonviral sexually transmitted infection worldwide. A reported 200 million cases are documented each yea...

    Authors: Michael Dirkx, Michael P Boyer, Prajakta Pradhan, Andrew Brittingham and Wayne A Wilson

    Citation: BMC Biochemistry 2014 15:12

    Content type: Research article

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  42. Organic solute carrier partner 1 (OSCP1) is known to facilitate the transport of various organic solutes into cells and reported to play a role in cell growth and cell differentiation. Moreover, OSCP1 is known...

    Authors: Nguyen Tho Huu, Hideki Yoshida, Takanari Umegawachi, Seiji Miyata and Masamitsu Yamaguchi

    Citation: BMC Biochemistry 2014 15:11

    Content type: Research article

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  43. In order to understand the effects of FeS cluster attachment in [NiFe] hydrogenase, we undertook a study to substitute all 12 amino acid positions normally ligating the three FeS clusters in the hydrogenase sm...

    Authors: Isaac T Yonemoto, Benjamin R Clarkson, Hamilton O Smith and Philip D Weyman

    Citation: BMC Biochemistry 2014 15:10

    Content type: Research article

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  44. Human malaria parasite infection and its control is a global challenge which is responsible for ~0.65 million deaths every year globally. The emergence of drug resistant malaria parasite is another challenge t...

    Authors: Mohammed Tarique, Farha Tabassum, Moaz Ahmad and Renu Tuteja

    Citation: BMC Biochemistry 2014 15:9

    Content type: Research article

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  45. The gene that encodes laforin, a dual-specificity phosphatase with a carbohydrate-binding module, is mutated in Lafora disease (LD). LD is an autosomal recessive, fatal progressive myoclonus epilepsy character...

    Authors: M Kathryn Brewer, Satrio Husodo, Vikas V Dukhande, Mary Beth Johnson and Matthew S Gentry

    Citation: BMC Biochemistry 2014 15:8

    Content type: Research article

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