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  1. Research article

    Conserved motif VIII of murine DNA methyltransferase Dnmt3a is essential for methylation activity

    Dnmt3a is a DNA methyltransferase that establishes de novo DNA methylation in mammals. The structure of the Dnmt3a C-terminal domain is similar to the bacterial M. HhaI enzyme, a well-studied prokaryotic DNA meth...

    Olga V. Lukashevich, Natalia A. Cherepanova, Renata Z. Jurkovska, Albert Jeltsch and Elizaveta S. Gromova

    BMC Biochemistry 2016 17:7

    Published on: 22 March 2016

  2. Research article

    1,2-Dichlorobenzene affects the formation of the phosphoenzyme stage during the catalytic cycle of the Ca2+-ATPase from sarcoplasmic reticulum

    1,2-Dichlorobenzene (1,2-DCB) is a benzene-derived molecule with two Cl atoms that is commonly utilized in the synthesis of pesticides. 1,2-DCB can be absorbed by living creatures and its effects on naturally-...

    Javier Vargas-Medrano, Jorge A. Sierra-Fonseca and Luis F. Plenge-Tellechea

    BMC Biochemistry 2016 17:5

    Published on: 11 March 2016

  3. Reviewer Acknowledgement

    BMC Biochemistry Reviewer Acknowledgement, 2015

    The editors of BMC Biochemistry would like to thank all our reviewers who have contributed their time to the journal in Volume 16 (2015).

    Guangde Tu

    BMC Biochemistry 2016 17:2

    Published on: 10 February 2016

  4. Research article

    Characterization of a cold-active and salt tolerant esterase identified by functional screening of Arctic metagenomic libraries

    The use of metagenomics in enzyme discovery constitutes a powerful approach to access to genomes of unculturable community of microorganisms and isolate novel valuable biocatalysts for use in a wide range of b...

    Concetta De Santi, Bjørn Altermark, Marcin Miroslaw Pierechod, Luca Ambrosino, Donatella de Pascale and Nils-Peder Willassen

    BMC Biochemistry 2016 17:1

    Published on: 19 January 2016

  5. Research article

    A comparison of the enzymatic properties of three recombinant isoforms of thrombolytic and antibacterial protein—Destabilase-Lysozyme from medicinal leech

    Destabilase-Lysozyme (mlDL) is a multifunctional i-type enzyme that has been found in the secretions from the salivary glands of medicinal leeches. mlDL has been shown to exhibit isopeptidase, muramidase and a...

    Alexey S. Kurdyumov, Valentin A. Manuvera, Isolda P. Baskova and Vassili N. Lazarev

    BMC Biochemistry 2015 16:27

    Published on: 21 November 2015

  6. Research article

    The GH5 1,4-β-mannanase from Bifidobacterium animalis subsp. lactis Bl-04 possesses a low-affinity mannan-binding module and highlights the diversity of mannanolytic enzymes

    β-Mannans are abundant and diverse plant structural and storage polysaccharides. Certain human gut microbiota members including health-promoting Bifidobacterium spp. catabolize dietary mannans. Little insight is ...

    Johan Morrill, Evelina Kulcinskaja, Anna Maria Sulewska, Sampo Lahtinen, Henrik Stålbrand, Birte Svensson and Maher Abou Hachem

    BMC Biochemistry 2015 16:26

    Published on: 11 November 2015

  7. Research article

    The eukaryotic translation initiation factor 3f (eIF3f) interacts physically with the alpha 1B-adrenergic receptor and stimulates adrenoceptor activity

    eIF3f is a multifunctional protein capable of interacting with proteins involved in different cellular processes, such as protein synthesis, DNA repair, and viral mRNA edition. In human cells, eIF3f is related...

    Mario Javier Gutiérrez-Fernández, Ana Edith Higareda-Mendoza, César Adrián Gómez-Correa and Marco Aurelio Pardo-Galván

    BMC Biochemistry 2015 16:25

    Published on: 23 October 2015

  8. Research article

    Evaluating the role of a trypsin inhibitor from soap nut (Sapindus trifoliatus L. Var. Emarginatus) seeds against larval gut proteases, its purification and characterization

    The defensive capacities of plant protease Inhibitors (PI) rely on inhibition of proteases in insect guts or those secreted by microorganisms; and also prevent uncontrolled proteolysis and offer protection aga...

    V D Sirisha Gandreddi, Vijaya Rachel Kappala, Kunal Zaveri and Kiranmayi Patnala

    BMC Biochemistry 2015 16:23

    Published on: 22 October 2015

  9. Research article

    Respiration and substrate transport rates as well as reactive oxygen species production distinguish mitochondria from brain and liver

    Aberrant mitochondrial function, including excessive reactive oxygen species (ROS) production, has been implicated in the pathogenesis of human diseases. The use of mitochondrial inhibitors to ascertain the si...

    Aaron M. Gusdon, Gabriel A. Fernandez-Bueno, Stephanie Wohlgemuth, Jenelle Fernandez, Jing Chen and Clayton E. Mathews

    BMC Biochemistry 2015 16:22

    Published on: 10 September 2015

  10. Research article

    Complex kinetics and residual structure in the thermal unfolding of yeast triosephosphate isomerase

    Saccharomyces cerevisiae triosephosphate isomerase (yTIM) is a dimeric protein that shows noncoincident unfolding and refolding transitions (hysteresis) in temperature scans, a phenome...

    Ariana Labastida-Polito, Georgina Garza-Ramos, Menandro Camarillo-Cadena, Rafael A. Zubillaga and Andrés Hernández-Arana

    BMC Biochemistry 2015 16:20

    Published on: 3 September 2015

  11. Research article

    Purification and characterization of a cytochrome c with novel caspase-3 activation activity from the pathogenic fungus Rhizopus arrhizus

    Members of Rhizopus species are the most common cause of mucormycosis, a rare but often fatal fungal infection. Host induced pathogen apoptosis and pathogen induced host cell apoptosis are often involved in funga...

    Manoj Saxena, Rohit Kumar Sharma, Josell Ramirez-Paz, Arthur D. Tinoco and Kai Griebenow

    BMC Biochemistry 2015 16:21

    Published on: 3 September 2015

    The Erratum to this article has been published in BMC Biochemistry 2016 17:3

  12. Research article

    Identification of inhibitors that target dual-specificity phosphatase 5 provide new insights into the binding requirements for the two phosphate pockets

    Dual-specificity phosphatase-5 (DUSP5) plays a central role in vascular development and disease. We present a p-nitrophenol phosphate (pNPP) based enzymatic assay to screen for inhibitors of the phosphatase domai...

    Terrence S. Neumann, Elise A. Span, Kelsey S. Kalous, Robert Bongard, Adam Gastonguay, Michael A. Lepley, Raman G. Kutty, Jaladhi Nayak, Chris Bohl, Rachel G. Lange, Majher I. Sarker, Marat R. Talipov, Rajendra Rathore, Ramani Ramchandran and Daniel S. Sem

    BMC Biochemistry 2015 16:19

    Published on: 19 August 2015

  13. Research article

    Design of symmetric TIM barrel proteins from first principles

    Computational protein design is a rapidly maturing field within structural biology, with the goal of designing proteins with custom structures and functions. Such proteins could find widespread medical and ind...

    Deepesh Nagarajan, Geeta Deka and Megha Rao

    BMC Biochemistry 2015 16:18

    Published on: 12 August 2015

  14. Research article

    Kv1.3 contains an alternative C-terminal ER exit motif and is recruited into COPII vesicles by Sec24a

    Potassium channels play a fundamental role in resetting the resting membrane potential of excitable cells. Determining the intracellular trafficking and localization mechanisms of potassium channels provides a...

    John M. Spear, Dolly Al Koborssy, Austin B. Schwartz, Adam J. Johnson, Anjon Audhya, Debra A. Fadool and Scott M. Stagg

    BMC Biochemistry 2015 16:16

    Published on: 10 July 2015

  15. Research article

    Human POLD1 modulates cell cycle progression and DNA damage repair

    The activity of eukaryotic DNA polymerase delta (Pol δ) plays an essential role in genome stability through its effects on DNA replication and repair. The p125 catalytic subunit of Pol δ is encoded by POLD1 gene ...

    Jing Song, Ping Hong, Chengeng Liu, Yueqi Zhang, Jinling Wang and Peichang Wang

    BMC Biochemistry 2015 16:14

    Published on: 19 June 2015

  16. Research article

    Sigma-1 receptor directly interacts with Rac1-GTPase in the brain mitochondria

    Small Rho-GTPases are critical mediators of neuronal plasticity and are involved in the pathogenesis of several psychiatric and neurological disorders. Rac-GTPase forms a multiprotein complex with upstream and...

    Nino Natsvlishvili, Nino Goguadze, Elene Zhuravliova and David Mikeladze

    BMC Biochemistry 2015 16:11

    Published on: 30 April 2015

  17. Research article

    Nickel quercetinase, a “promiscuous” metalloenzyme: metal incorporation and metal ligand substitution studies

    Quercetinases are metal-dependent dioxygenases of the cupin superfamily. While fungal quercetinases are copper proteins, recombinant Streptomyces quercetinase (QueD) was previously described to be capable of inco...

    Dimitrios Nianios, Sven Thierbach, Lenz Steimer, Pavel Lulchev, Dagmar Klostermeier and Susanne Fetzner

    BMC Biochemistry 2015 16:10

    Published on: 23 April 2015

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