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  1. A novel fluorescent cAMP analog (8-[Pharos-575]- adenosine-3', 5'-cyclic monophosphate) was characterized with respect to its spectral properties, its ability to bind to and activate three main isoenzymes of t...

    Authors: Daniela Moll, Anke Prinz, Cornelia M Brendel, Marco Berrera, Katrin Guske, Manuela Zaccolo, Hans-Gottfried Genieser and Friedrich W Herberg
    Citation: BMC Biochemistry 2008 9:18
  2. The pyridoxal-5'-phosphate (PLP)-dependent or vitamin B6-dependent enzymes that catalyze manifold reactions in the metabolism of amino acids belong to no fewer than four evolutionarily independent protein familie...

    Authors: Rosa A Vacca, Sergio Giannattasio, Guido Capitani, Ersilia Marra and Philipp Christen
    Citation: BMC Biochemistry 2008 9:17
  3. An interaction between lectins from marine algae and PLA2 from rattlesnake was suggested some years ago. We, herein, studied the effects elicited by a small isolectin (BTL-2), isolated from Bryothamnion triquetru...

    Authors: Simone CB Oliveira, Fabiana V Fonseca, Edson Antunes, Enilton A Camargo, Rafael P Morganti, Ricardo Aparício, Daniela O Toyama, Luís OS Beriam, Eudismar V Nunes, Benildo S Cavada, Celso S Nagano, Alexandre H Sampaio, Kyria S Nascimento and Marcos H Toyama
    Citation: BMC Biochemistry 2008 9:16
  4. Arginase (RocF) hydrolyzes L-arginine to L-ornithine and urea. While previously characterized arginases have an alkaline pH optimum and require activation with manganese, arginase from Helicobacter pylori is opti...

    Authors: Ryan J Viator, Richard F Rest, Ellen Hildebrandt and David J McGee
    Citation: BMC Biochemistry 2008 9:15
  5. Nucleases, which are key components of biologically diverse processes such as DNA replication, repair and recombination, antiviral defense, apoptosis and digestion, have revolutionized the field of molecular b...

    Authors: Veronika E Anisimova, Denis V Rebrikov, Dmitry A Shagin, Valery B Kozhemyako, Natalia I Menzorova, Dmitry B Staroverov, Rustam Ziganshin, Laura L Vagner, Valery A Rasskazov, Sergey A Lukyanov and Alex S Shcheglov
    Citation: BMC Biochemistry 2008 9:14
  6. The emergence of multi- and extensively-drug resistant Mycobacterium tuberculosis strains has created an urgent need for new agents to treat tuberculosis (TB). The enzymes of shikimate pathway are attractive targ...

    Authors: Fernanda Ely, José ES Nunes, Evelyn K Schroeder, Jeverson Frazzon, Mário S Palma, Diógenes S Santos and Luiz A Basso
    Citation: BMC Biochemistry 2008 9:13
  7. Rieske non-heme iron aromatic ring-hydroxylating oxygenases (RHOs) are multi-component enzyme systems that are remarkably diverse in bacteria isolated from diverse habitats. Since the first classification in 1...

    Authors: Ohgew Kweon, Seong-Jae Kim, Songjoon Baek, Jong-Chan Chae, Michael D Adjei, Dong-Heon Baek, Young-Chang Kim and Carl E Cerniglia
    Citation: BMC Biochemistry 2008 9:11
  8. Reversible phosphorylation events within a polymerisation complex have been proposed to modulate capsular polysaccharide synthesis in Streptococcus pneumoniae. Similar phosphatase and kinase genes are present in ...

    Authors: Gisèle LaPointe, Danièle Atlan and Christophe Gilbert
    Citation: BMC Biochemistry 2008 9:10
  9. Repulsive guidance molecule c (RGMc or hemojuvelin), a glycosylphosphatidylinositol-linked glycoprotein expressed in liver and striated muscle, plays a central role in systemic iron balance. Inactivating mutat...

    Authors: David Kuninger, Robin Kuns-Hashimoto, Mahta Nili and Peter Rotwein
    Citation: BMC Biochemistry 2008 9:9
  10. Inulosucrase (IslA) from Leuconostoc citreum CW28 belongs to a new subfamily of multidomain fructosyltransferases (FTFs), containing additional domains from glucosyltransferases. It is not known what the function...

    Authors: Sandra del Moral, Clarita Olvera, Maria Elena Rodriguez and Agustin Lopez Munguia
    Citation: BMC Biochemistry 2008 9:6
  11. Functional immunoglobulin and T cell receptor genes are produced in developing lymphocytes by V(D)J recombination. The initial site-specific DNA cleavage steps in this process are catalyzed by the V(D)J recomb...

    Authors: Pallabi De, Shuying Zhao, Lori M Gwyn, LeAnn J Godderz, Mandy M Peak and Karla K Rodgers
    Citation: BMC Biochemistry 2008 9:5
  12. The delivery of ubiquitinated proteins to the proteasome for degradation is a key step in the regulation of the ubiquitin-proteasome pathway, yet the mechanisms underlying this step are not understood in detai...

    Authors: Amanda M Goh, Kylie J Walters, Suzanne Elsasser, Rati Verma, Raymond J Deshaies, Daniel Finley and Peter M Howley
    Citation: BMC Biochemistry 2008 9:4
  13. Bacillus thuringiensis Cry1Aa insecticidal protein is the most active known B. thuringiensis toxin against the forest insect pest Lymantria dispar (gypsy moth), unfortunately it is also highly toxic against the n...

    Authors: Taek H You, Mi K Lee, Jeremy L Jenkins, Oscar Alzate and Donald H Dean
    Citation: BMC Biochemistry 2008 9:3
  14. Vibrio carchariae chitinase A (EC3.2.1.14) is a family-18 glycosyl hydrolase and comprises three distinct structural domains: i) the amino terminal chitin binding domain (ChBD); ii) the (α/β)8 TIM barrel catalyti...

    Authors: Supansa Pantoom, Chomphunuch Songsiriritthigul and Wipa Suginta
    Citation: BMC Biochemistry 2008 9:2
  15. Cullin-RING ubiquitin E3 ligases (CRLs) are regulated by modification of an ubiquitin-like protein, Nedd8 (also known as Rub1) on the cullin subunit. Neddylation is shown to facilitate E3 complex assembly; whi...

    Authors: Suchithra Menon, Tomohiko Tsuge, Naoshi Dohmae, Koji Takio and Ning Wei
    Citation: BMC Biochemistry 2008 9:1
  16. Eps15 homology (EH) domains are protein interaction modules binding to peptides containing Asn-Pro-Phe (NPF) motifs and mediating critical events during endocytosis and signal transduction. The EH domain of PO...

    Authors: Elena Santonico, Simona Panni, Mattia Falconi, Luisa Castagnoli and Gianni Cesareni
    Citation: BMC Biochemistry 2007 8:29
  17. The COP9 signalosome (CSN) is a conserved protein complex in eukaryotic cells consisting of eight subunits (CSN1 to CSN8). Recent data demonstrate that the CSN is a regulator of the ubiquitin (Ub) proteasome s...

    Authors: Andreas Peth, Christoph Berndt, Wolfgang Henke and Wolfgang Dubiel
    Citation: BMC Biochemistry 2007 8:27
  18. Cancer, like other diseases accompanied by strong metabolic disorders, shows characteristic effects on cell turnover rate, activity of modifying enzymes and DNA/RNA modifications, resulting also in elevated am...

    Authors: Dino Bullinger, Hans Neubauer, Tanja Fehm, Stefan Laufer, Christoph H Gleiter and Bernd Kammerer
    Citation: BMC Biochemistry 2007 8:25
  19. The Ca2+-binding protein recoverin operates as a Ca2+-sensor in vertebrate photoreceptor cells. It undergoes a so-called Ca2+-myristoyl switch when cytoplasmic Ca2+-concentrations fluctuate in the cell. Its coval...

    Authors: Ivan I Senin, Valeriya A Churumova, Pavel P Philippov and Karl-Wilhelm Koch
    Citation: BMC Biochemistry 2007 8:24
  20. Deregulation of the ubiquitin proteasome system (UPS) has been implicated in the pathogenesis of many human diseases, including cancer and neurodegenerative disorders. The recent approval of the proteasome inh...

    Authors: Philippe Guédat and Frédéric Colland
    Citation: BMC Biochemistry 2007 8(Suppl 1):S14

    This article is part of a Supplement: Volume 8 Supplement 1

  21. Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Although a subject of intense research, the etiology of PD remains poorly understood. Recently, several lines of evidence have i...

    Authors: Kah-Leong Lim and Jeanne MM Tan
    Citation: BMC Biochemistry 2007 8(Suppl 1):S13

    This article is part of a Supplement: Volume 8 Supplement 1

  22. Though Alzheimer's disease (AD) is a syndrome with well-defined clinical and neuropathological manifestations, an array of molecular defects underlies its pathology. A role for the ubiquitin proteasome system ...

    Authors: Sudarshan C Upadhya and Ashok N Hegde
    Citation: BMC Biochemistry 2007 8(Suppl 1):S12

    This article is part of a Supplement: Volume 8 Supplement 1

  23. CF is an inherited autosomal recessive disease whose lethality arises from malfunction of CFTR, a single chloride (Cl-) ion channel protein. CF patients harbor mutations in the CFTR gene that lead to misfolding o...

    Authors: Emma L Turnbull, Meredith FN Rosser and Douglas M Cyr
    Citation: BMC Biochemistry 2007 8(Suppl 1):S11

    This article is part of a Supplement: Volume 8 Supplement 1

  24. Fanconi anemia (FA) is a rare genetic disorder characterized by aplastic anemia, cancer/leukemia susceptibility and cellular hypersensitivity to DNA crosslinking agents, such as cisplatin. To date, 12 FA gene ...

    Authors: Céline Jacquemont and Toshiyasu Taniguchi
    Citation: BMC Biochemistry 2007 8(Suppl 1):S10

    This article is part of a Supplement: Volume 8 Supplement 1

  25. Recently, the ubiquitin proteasome system (UPS) has matured as a drug discovery arena, largely on the strength of the proven clinical activity of the proteasome inhibitor Velcade in multiple myeloma. Ubiquitin...

    Authors: Timothy Cardozo and Michele Pagano
    Citation: BMC Biochemistry 2007 8(Suppl 1):S9

    This article is part of a Supplement: Volume 8 Supplement 1

  26. Tumor viruses are linked to approximately 20% of human malignancies worldwide. This review focuses on examples of human oncogenic viruses that manipulate the ubiquitin system in a subset of viral malignancies;...

    Authors: Julia Shackelford and Joseph S Pagano
    Citation: BMC Biochemistry 2007 8(Suppl 1):S8

    This article is part of a Supplement: Volume 8 Supplement 1

  27. Muscle wasting, characterized by the loss of protein mass in myofibers, is in most cases largely due to the activation of intracellular protein degradation by the ubiquitin proteasome system (UPS). During the ...

    Authors: David Nury, Christine Doucet and Olivier Coux
    Citation: BMC Biochemistry 2007 8(Suppl 1):S7

    This article is part of a Supplement: Volume 8 Supplement 1

  28. In a simplified view, members of the HECT E3 family have a modular structure consisting of the C-terminal HECT domain, which is catalytically involved in the attachment of ubiquitin to substrate proteins, and ...

    Authors: Martin Scheffner and Olivier Staub
    Citation: BMC Biochemistry 2007 8(Suppl 1):S6

    This article is part of a Supplement: Volume 8 Supplement 1

  29. A functional ubiquitin proteasome system is essential for all eukaryotic cells and therefore any alteration to its components has potential pathological consequences. Though the exact underlying mechanism is u...

    Authors: Burkhardt Dahlmann
    Citation: BMC Biochemistry 2007 8(Suppl 1):S3

    This article is part of a Supplement: Volume 8 Supplement 1

  30. Huntington's disease and several of the spinocerebellar ataxias are caused by the abnormal expansion of a CAG repeat within the coding region of the disease gene. This results in the production of a mutant pro...

    Authors: Janet E Davies, Sovan Sarkar and David C Rubinsztein
    Citation: BMC Biochemistry 2007 8(Suppl 1):S2

    This article is part of a Supplement: Volume 8 Supplement 1

  31. The human genome encodes several ubiquitin-like (UBL) domain proteins (UDPs). Members of this protein family are involved in a variety of cellular functions and many are connected to the ubiquitin proteasome s...

    Authors: Louise Madsen, Andrea Schulze, Michael Seeger and Rasmus Hartmann-Petersen
    Citation: BMC Biochemistry 2007 8(Suppl 1):S1

    This article is part of a Supplement: Volume 8 Supplement 1

  32. Genetic variants in the FTO (fat mass and obesity associated) gene have been associated with an increased risk of obesity. However, the function of its protein product has not been experimentally studied and prev...

    Authors: Luis Sanchez-Pulido and Miguel A Andrade-Navarro
    Citation: BMC Biochemistry 2007 8:23
  33. The RNA recognition motif (RRM) is one of the largest families of RNA binding domains. The RRM is modulated so that individual proteins containing RRMs can specifically recognize RNA targets with diverse seque...

    Authors: Yulia Benitex and Anne M Baranger
    Citation: BMC Biochemistry 2007 8:22
  34. Aminopeptidase B (Ap-B; EC catalyzes the cleavage of basic residues at the N-terminus of peptides and processes glucagon into miniglucagon. The enzyme exhibits, in vitro, a residual ability to hydrolyze...

    Authors: Viet-Laï Pham, Marie-Sandrine Cadel, Cécile Gouzy-Darmon, Chantal Hanquez, Margery C Beinfeld, Pierre Nicolas, Catherine Etchebest and Thierry Foulon
    Citation: BMC Biochemistry 2007 8:21
  35. Type I hexokinase (HK-I) constitutes the predominant form of the enzyme in the brain, a major portion of which is associated with the outer mitochondrial membrane involving two sets of binding sites. In additi...

    Authors: Abolfazl Golestani, Hassan Ramshini and Mohsen Nemat-Gorgani
    Citation: BMC Biochemistry 2007 8:20
  36. Human extracellular superoxide dismutase (EC-SOD) is a tetrameric metalloenzyme responsible for the removal of superoxide anions from the extracellular space. We have previously shown that the EC-SOD subunit e...

    Authors: Steen V Petersen, Zuzana Valnickova, Tim D Oury, James D Crapo, Niels Chr Nielsen and Jan J Enghild
    Citation: BMC Biochemistry 2007 8:19
  37. Heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins), composed of Gα, Gβ, and Gγ subunits, are positioned at the inner face of the plasma membrane and relay signals from activated G prote...

    Authors: Lylia Nini, Abdul A Waheed, Leelamma M Panicker, Meggan Czapiga, Jian-Hua Zhang and William F Simonds
    Citation: BMC Biochemistry 2007 8:18
  38. We have recently identified a new thiamine derivative, adenosine thiamine triphosphate (AThTP), in E. coli. In intact bacteria, this nucleotide is synthesized only in the absence of a metabolizable carbon source ...

    Authors: Alexander F Makarchikov, Alain Brans and Lucien Bettendorff
    Citation: BMC Biochemistry 2007 8:17
  39. Spt7 is an integral component of the multi-subunit SAGA complex that is required for the expression of ~10% of yeast genes. Two forms of Spt7 have been identified, the second of which is truncated at its C-ter...

    Authors: Stephen MT Hoke, Gaoyang Liang, A Irina Mutiu, Julie Genereaux and Christopher J Brandl
    Citation: BMC Biochemistry 2007 8:16
  40. Interphotoreceptor retinoid-binding protein's (IRBP) remarkable module structure may be critical to its role in mediating the transport of all-trans and 11-cis retinol, and 11-cis retinal between rods, cones, RPE...

    Authors: Federico Gonzalez-Fernandez, Claxton A Baer and Debashis Ghosh
    Citation: BMC Biochemistry 2007 8:15
  41. We describe the database ExplorEnz, which is the primary repository for EC numbers and enzyme data that are being curated on behalf of the IUBMB. The enzyme nomenclature is incorporated into many other resourc...

    Authors: Andrew G McDonald, Sinéad Boyce, Gerard P Moss, Henry BF Dixon and Keith F Tipton
    Citation: BMC Biochemistry 2007 8:14
  42. Frataxin is discussed as involved in the biogenesis of iron-sulfur clusters. Recently it was discovered that a frataxin homologue is a structural component of the respiratory NADH:ubiquinone oxidoreductase (co...

    Authors: Thomas Pohl, Julia Walter, Stefan Stolpe, Joel H Defeu Soufo, Peter L Grauman and Thorsten Friedrich
    Citation: BMC Biochemistry 2007 8:13