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  1. Defensins are basic, cysteine-rich antimicrobial peptides that are important components of plant defense against pathogens. Previously, we isolated a defensin, Pv D1, from Phaseolus vulgaris L. (common bean) seed...

    Authors: Érica de O Mello, Izabela S dos Santos, André de O Carvalho, Luísa S de Souza, Gonçalo A de Souza-Filho, Viviane V do Nascimento, Olga LT Machado, Umberto Zottich and Valdirene M Gomes

    Citation: BMC Biochemistry 2014 15:7

    Content type: Research article

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  2. Calciotropic hormones were thought to facilitate calcium transfer through active transcellular or passive paracellular pathway for calcium homeostasis. While calcium transport proteins such as CaBP-28 k, TRPV5...

    Authors: Inho Hwang, Eui-Ju Hong, Hyun Yang, Hong-Seok Kang, Changhwan Ahn, Beum-Soo An and Eui-Bae Jeung

    Citation: BMC Biochemistry 2014 15:6

    Content type: Research article

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  3. Carbohydrate-deficient transferrin (CDT) is a widely used alcohol biomarker. Because of the high prevalence of chronic alcohol abuse in many countries, CDT plays an important role in the areas of traffic, clin...

    Authors: Binbin Song, Jing Zhu, Jiong Wu, Chunyan Zhang, Beili Wang, Baishen Pan and Wei Guo

    Citation: BMC Biochemistry 2014 15:5

    Content type: Methodology article

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  4. Autophagy is a cellular response to intracellular pathogens including mycobacteria and is induced by the direct inhibitors of mammalian target of Rapamycin (mTOR), a major negative regulator of autophagy. Auto...

    Authors: Alfred J Zullo, Kristen L Jurcic Smith and Sunhee Lee

    Citation: BMC Biochemistry 2014 15:4

    Content type: Research article

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  5. Endoplasmic reticulum stress, caused by the presence of misfolded proteins, activates the stress sensor inositol-requiring enzyme 1α (IRE1α). The resulting increase in IRE1α RNase activity causes sequence-spec...

    Authors: Daniel Itzhak, Michael Bright, Peter McAndrew, Amin Mirza, Yvette Newbatt, Jade Strover, Marcella Widya, Andrew Thompson, Gareth Morgan, Ian Collins and Faith Davies

    Citation: BMC Biochemistry 2014 15:3

    Content type: Research article

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  6. We have previously shown that the P. gingivalis HmuY hemophore-like protein binds heme and scavenges heme from host hemoproteins to further deliver it to the cognate heme receptor HmuR. The aim of this study was ...

    Authors: Marcin Bielecki, Halina Wójtowicz and Teresa Olczak

    Citation: BMC Biochemistry 2014 15:2

    Content type: Research article

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  7. The regulation of lipid biosynthesis is essential in photosynthetic eukaryotic cells. This regulation occurs during the direct synthesis of fatty acids and triacylglycerols (TAGs), as well as during other cont...

    Authors: Xiaodong Deng, Jiajia Cai and Xiaowen Fei

    Citation: BMC Biochemistry 2013 14:38

    Content type: Research article

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  8. Heterotrimeric G-proteins relay extracellular signals to intracellular effector proteins. Multiple methods have been developed to monitor their activity; including labeled nucleotides and biosensors based on g...

    Authors: Lauri Tõntson, Sergei Kopanchuk and Ago Rinken

    Citation: BMC Biochemistry 2013 14:37

    Content type: Research article

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  9. Dihydroorotase (DHO) is a zinc metalloenzyme, although the number of active site zinc ions has been controversial. E. coli DHO was initially thought to have a mononuclear metal center, but the subsequent X-ray st...

    Authors: Brian FP Edwards, Roshini Fernando, Philip D Martin, Edward Grimley, Melissa Cordes, Asmita Vaishnav, Joseph S Brunzelle, Hedeel Guy Evans and David R Evans

    Citation: BMC Biochemistry 2013 14:36

    Content type: Research article

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  10. Peroxidases are emerging as an important class of enzymes that can be used for the efficient degradation of organic pollutants. However, detailed studies identifying the various intermediates produced and the ...

    Authors: Liaquat Ali, Rowdha Algaithi, Hosam M Habib, Usama Souka, Muhammad A Rauf and S Salman Ashraf

    Citation: BMC Biochemistry 2013 14:35

    Content type: Research article

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  11. Huntington’s disease (HD) is a monogenic disorder caused by an aberrant expansion of CAG repeats in the huntingtin gene (HTT). Pathogenesis is associated with expression of the mutant (mHTT) protein in the CNS, w...

    Authors: Luisa Massai, Lara Petricca, Letizia Magnoni, Luca Rovetini, Salman Haider, Ralph Andre, Sarah J Tabrizi, Sigurd D Süssmuth, Bernhard G Landwehrmeyer, Andrea Caricasole, Giuseppe Pollio and Simonetta Bernocco

    Citation: BMC Biochemistry 2013 14:34

    Content type: Methodology article

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  12. Proteases are important enzymes involved in numerous essential physiological processes and hold a strong potential for industrial applications. The proteolytic activity of insects’ gut is endowed by many isofo...

    Authors: Prashant T Sanatan, Purushottam R Lomate, Ashok P Giri and Vandana K Hivrale

    Citation: BMC Biochemistry 2013 14:32

    Content type: Research article

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  13. Alpha-1 proteinase inhibitor (API) is a plasma serpin superfamily member that inhibits neutrophil elastase; variant API M358R inhibits thrombin and activated protein C (APC). Fusing residues 1-75 of another se...

    Authors: Leigh Ann Roddick, Varsha Bhakta and William P Sheffield

    Citation: BMC Biochemistry 2013 14:31

    Content type: Research article

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  14. YedY, a molybdoenzyme belonging to the sulfite oxidase family, is found in most Gram-negative bacteria. It contains a twin-arginine signal sequence that is cleaved after its translocation into the periplasm. D...

    Authors: Monique Sabaty, Sandrine Grosse, Geraldine Adryanczyk, Séverine Boiry, Frédéric Biaso, Pascal Arnoux and David Pignol

    Citation: BMC Biochemistry 2013 14:28

    Content type: Research article

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  15. BTBD10 binds to Akt and protein phosphatase 2A (PP2A) and inhibits the PP2A-mediated dephosphorylation of Akt, thereby keeping Akt activated. Previous studies have suggested that BTBD10 plays an important role...

    Authors: Mikiro Nawa and Masaaki Matsuoka

    Citation: BMC Biochemistry 2013 14:27

    Content type: Research article

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  16. Methylmalonyl-CoA mutase (MCM) is an adenosylcobalamin-dependent enzyme that catalyses the interconversion of (2R)-methylmalonyl-CoA to succinyl-CoA. In humans, a deficit in activity of MCM, due to an impairme...

    Authors: Bazoumana Ouattara, Mélissa Duplessis and Christiane L Girard

    Citation: BMC Biochemistry 2013 14:25

    Content type: Methodology article

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  17. Vitamin C (ascorbic acid) is an essential nutrient of most living tissues that readily acts as a strong reducing agent, which is abundant in fruits and vegetables. Although, it inhibits cell growth in many hum...

    Authors: Arulkumar Nagappan, Hyeon Soo Park, Kwang Il Park, Jin A Kim, Gyeong Eun Hong, Sang Rim Kang, Jue Zhang, Eun Hee Kim, Won Sup Lee, Chung Kil Won and Gon Sup Kim

    Citation: BMC Biochemistry 2013 14:24

    Content type: Research article

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  18. Streptomyces sp. N174 chitosanase (CsnN174), a member of glycoside hydrolases family 46, is one of the most extensively studied chitosanases. Previous studies allowed identifying several key residues of this inve...

    Authors: Marie-Ève Lacombe-Harvey, Mélanie Fortin, Takayuki Ohnuma, Tamo Fukamizo, Thomas Letzel and Ryszard Brzezinski

    Citation: BMC Biochemistry 2013 14:23

    Content type: Research article

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  19. Transforming growth factor-betas (TGF-βs), including beta2 (TGF-β2), constitute a superfamily of multifunctional cytokines with important implications in morphogenesis, cell differentiation and tissue remodeli...

    Authors: Yan-Bin XiYang, Fang Wang, Bao-Jiang Qian, Ling You, Bing-Tuan Lu, Wei Zhang, Xiong-Zhi Quan, Wen-Ping Ge, Su Liu, Lian-Feng Zhang and Ting-Hua Wang

    Citation: BMC Biochemistry 2013 14:21

    Content type: Research article

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  20. The cytochrome P450s are monooxygenases that insert oxygen functionalities into a wide variety of organic substrates with high selectivity. There is interest in developing efficient catalysts based on the “per...

    Authors: James E Erman, Heather Kilheeney, Anil K Bidwai, Caitlan E Ayala and Lidia B Vitello

    Citation: BMC Biochemistry 2013 14:19

    Content type: Research article

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  21. Lamins A and C, two major structural components of the nuclear lamina that determine nuclear shape and size, are phosphoproteins. Phosphorylation of lamin A/C is cell cycle-dependent and is involved in regulat...

    Authors: Jeng-Ting Chen, Chia-Wen Ho, Lang-Ming Chi, Kun-Yi Chien, Ya-Ju Hsieh, Shih-Jie Lin and Jau-Song Yu

    Citation: BMC Biochemistry 2013 14:18

    Content type: Research article

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  22. Signal peptide peptidase (SPP) is a multi-transmembrane aspartic protease involved in intramembrane-regulated proteolysis (RIP). RIP proteases mediate various key life events by releasing bioactive peptides fr...

    Authors: Masako Hoshi, Yu Ohki, Keisuke Ito, Taisuke Tomita, Takeshi Iwatsubo, Yoshiro Ishimaru, Keiko Abe and Tomiko Asakura

    Citation: BMC Biochemistry 2013 14:16

    Content type: Research article

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  23. α-Dystroglycan (α-DG) is heavily glycosylated within its central mucin-like domain. The glycosylation shell of α-dystroglycan is known to largely influence its functional properties toward extracellular ligand...

    Authors: Manuela Bozzi, Enrico Di Stasio, Giovanni Luca Scaglione, Claudia Desiderio, Claudia Martelli, Bruno Giardina, Francesca Sciandra and Andrea Brancaccio

    Citation: BMC Biochemistry 2013 14:15

    Content type: Research article

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  24. Non-steroidal anti-inflammatory drugs (NSAIDs) —aspirin, naproxen, nimesulide, and piroxicam— lowered activation of type II cAMP-dependent protein kinase A (PKA-II) in isolated rat adipocytes, decreasing adren...

    Authors: Héctor Vázquez-Meza, Martha Zentella de Piña, Juan Pablo Pardo, Héctor Riveros-Rosas, Rafael Villalobos-Molina and Enrique Piña

    Citation: BMC Biochemistry 2013 14:13

    Content type: Research article

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  25. The improvement of biomedical properties, e.g. biocompatibility, of poly(3-hydroxyalkanoates) (PHAs) by copolymerization is a promising trend in bioengineering. We used strain Azotobacter chroococcum 7B, an effec...

    Authors: Anton P Bonartsev, Sergey G Yakovlev, Irina I Zharkova, Arasha P Boskhomdzhiev, Dmitrii V Bagrov, Vera L Myshkina, Tatiana K Makhina, Elena P Kharitonova, Olga V Samsonova, Alexey V Feofanov, Vera V Voinova, Anton L Zernov, Yurii M Efremov, Garina A Bonartseva, Konstantin V Shaitan and Michail P Kirpichnikov

    Citation: BMC Biochemistry 2013 14:12

    Content type: Research article

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  26. The androgen receptor (AR) is a member of the nuclear receptor (NR) superfamily of ligand-inducible DNA transcription factors, and is the major mediator of male sexual development, prostate growth and the path...

    Authors: Daniel Abankwa, Susan M Millard, Nick Martel, Catherine S Choong, Miao Yang, Lisa M Butler, Grant Buchanan, Wayne D Tilley, Nobuhide Ueki, Michael J Hayman and Gary M Leong

    Citation: BMC Biochemistry 2013 14:10

    Content type: Research article

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  27. Analysis of factors contributing to high affinity antibody-protein interactions provides insight into natural antibody evolution, and guides the design of antibodies with new or enhanced function. We previousl...

    Authors: Alex Stewart, Joseph S Harrison, Lauren K Regula and Jonathan R Lai

    Citation: BMC Biochemistry 2013 14:9

    Content type: Research article

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  28. Conjugation of the ubiquitin-like modifier Nedd8 to cullins is critical for the function of SCF-type ubiquitin ligases and thus facilitates ubiquitin conjugation and ultimately degradation of SCF substrates, i...

    Authors: Jean E O’Donoghue, Dawadschargal Bech-Otschir, Ida B Larsen, Mairi Wallace, Rasmus Hartmann-Petersen and Colin Gordon

    Citation: BMC Biochemistry 2013 14:8

    Content type: Research article

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  29. Heparin cofactor II (HCII) is a circulating protease inhibitor, one which contains an N-terminal acidic extension (HCII 1-75) unique within the serpin superfamily. Deletion of HCII 1-75 greatly reduces the abi...

    Authors: Amanda J Boyle, Leigh Ann Roddick, Varsha Bhakta, Melissa D Lambourne, Murray S Junop, Patricia C Liaw, Jeffrey I Weitz and William P Sheffield

    Citation: BMC Biochemistry 2013 14:6

    Content type: Research article

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  30. Receptor tyrosine kinases (RTKs) are crucial components of signal transduction systems in multicellular animals. Surprisingly, numerous RTKs have been identified in the genomes of unicellular choanoflagellates...

    Authors: Kira P Schultheiss, Barbara P Craddock, Michael Tong, Markus Seeliger and W Todd Miller

    Citation: BMC Biochemistry 2013 14:4

    Content type: Research article

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  31. Hepatoma-derived growth factor (HDGF) is a protein which is highly expressed in a variety of tumours. HDGF has mitogenic, angiogenic, neurotrophic and antiapoptotic activity but the molecular mechanisms by whi...

    Authors: Stephanie Bremer, Katharina Klein, Angela Sedlmaier, Mekky Abouzied, Volkmar Gieselmann and Sebastian Franken

    Citation: BMC Biochemistry 2013 14:2

    Content type: Research article

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  32. The α-isoform of the Type 1A Phosphoinositide 3-kinases (PI3Kα) has protein kinase activity as well as phosphoinositide lipid kinase activity. The best described substrate for its protein kinase activity is it...

    Authors: Meredith J Layton, Mirette Saad, Nicole L Church, Richard B Pearson, Christina A Mitchell and Wayne A Phillips

    Citation: BMC Biochemistry 2012 13:30

    Content type: Research article

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  33. An important controversy in the relationship between beef tenderness and muscle characteristics including biochemical traits exists among meat researchers. The aim of this study is to explain variability in me...

    Authors: Sghaier Chriki, Graham E Gardner, Catherine Jurie, Brigitte Picard, Didier Micol, Jean-Paul Brun, Laurent Journaux and Jean-Francois Hocquette

    Citation: BMC Biochemistry 2012 13:29

    Content type: Research article

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  34. Presenilin-1 (PS1) is a transmembrane protein first discovered because of its association with familial Alzheimer’s disease. Mice with null mutations in PS1 die shortly after birth exhibiting multiple CNS and ...

    Authors: Rita De Gasperi, Miguel A Gama Sosa and Gregory A Elder

    Citation: BMC Biochemistry 2012 13:28

    Content type: Research article

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  35. Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) phosphorylates and activates particular downstream protein kinases — including CaMKI, CaMKIV, and AMPK— to stimulate multiple Ca2+-signal transduction pathw...

    Authors: Saki Yurimoto, Tomohito Fujimoto, Masaki Magari, Naoki Kanayama, Ryoji Kobayashi and Hiroshi Tokumitsu

    Citation: BMC Biochemistry 2012 13:27

    Content type: Research article

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