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Cellular and membrane biochemistry

Section edited by Chris Grant

This section incorporates all aspects of cellular and membrane biochemistry, including but not limited to: cell signaling and trafficking, chemical biology of the cell, membrane proteins and energy transduction, and macromolecular chemistry.

  1. Sepsis is a severe condition characterised by the body’s systemic inflammatory response to infection. The specific sepsis-related biomarkers should be used in clinical diagnosis, therapeutic response monitorin...

    Authors: Yanqiang Hou, Dongyu Liang, Yang Liu, Hongwei Chen and Xiaoli Lou

    Citation: BMC Biochemistry 2018 19:13

    Content type: Research article

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  2. Corynebacterium urealyticum, a pathogenic, multidrug resistant member of the mycolata, is known as causative agent of urinary tract infections although it is a bacterium of the skin flora. This pathogenic bacteri...

    Authors: Narges Abdali, Farhan Younas, Samaneh Mafakheri, Karunakar R. Pothula, Ulrich Kleinekathöfer, Andreas Tauch and Roland Benz

    Citation: BMC Biochemistry 2018 19:3

    Content type: Research article

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  3. The mechanistic target of rapamycin complex 1 (mTORC1) is a well-conserved serine/threonine protein kinase that controls autophagy as well as many other processes such as protein synthesis, cell growth, and me...

    Authors: Hongjie Pan, Xiao-ping Zhong and Sunhee Lee

    Citation: BMC Biochemistry 2016 17:14

    Content type: Research article

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  4. eIF3f is a multifunctional protein capable of interacting with proteins involved in different cellular processes, such as protein synthesis, DNA repair, and viral mRNA edition. In human cells, eIF3f is related...

    Authors: Mario Javier Gutiérrez-Fernández, Ana Edith Higareda-Mendoza, César Adrián Gómez-Correa and Marco Aurelio Pardo-Galván

    Citation: BMC Biochemistry 2015 16:25

    Content type: Research article

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  5. Aberrant mitochondrial function, including excessive reactive oxygen species (ROS) production, has been implicated in the pathogenesis of human diseases. The use of mitochondrial inhibitors to ascertain the si...

    Authors: Aaron M. Gusdon, Gabriel A. Fernandez-Bueno, Stephanie Wohlgemuth, Jenelle Fernandez, Jing Chen and Clayton E. Mathews

    Citation: BMC Biochemistry 2015 16:22

    Content type: Research article

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  6. Potassium channels play a fundamental role in resetting the resting membrane potential of excitable cells. Determining the intracellular trafficking and localization mechanisms of potassium channels provides a...

    Authors: John M. Spear, Dolly Al Koborssy, Austin B. Schwartz, Adam J. Johnson, Anjon Audhya, Debra A. Fadool and Scott M. Stagg

    Citation: BMC Biochemistry 2015 16:16

    Content type: Research article

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  7. The Arabidopsis thaliana protein atTic20 is a key component of the protein import machinery at the inner envelope membrane of chloroplasts. As a component of the TIC complex, it is believed to form a preprotein-c...

    Authors: James H Campbell, Tuan Hoang, Masoud Jelokhani-Niaraki and Matthew D Smith

    Citation: BMC Biochemistry 2014 15:29

    Content type: Research article

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  8. Human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomesase, is responsible for telomere maintenance and its reactivation is implicated in almost 90% human cancers. Recent evidences sho...

    Authors: Xu Cao, Chiou Mee Kong, Kanchi Madhu Mathi, Yoon Pin Lim, Valere Cacheux-Rataboul and Xueying Wang

    Citation: BMC Biochemistry 2014 15:17

    Content type: Research article

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  9. Secreted luciferases are highly useful bioluminescent reporters for cell-based assays and drug discovery. A variety of secreted luciferases from marine organisms have been described that harbor an N-terminal s...

    Authors: Christin Luft, Jamie Freeman, David Elliott, Nadia Al-Tamimi, Janos Kriston-Vizi, Jacob Heintze, Ida Lindenschmidt, Brian Seed and Robin Ketteler

    Citation: BMC Biochemistry 2014 15:14

    Content type: Methodology article

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  10. During EGFR internalization CIN85 bridges EGFR-Cbl complex, endocytic machinery and fusible membrane through the interactions of CIN85 with c-Cbl, endophilins and phosphatidic acid. These protein-protein and p...

    Authors: Xiudan Zheng, Jing Zhang and Kan Liao

    Citation: BMC Biochemistry 2014 15:13

    Content type: Research article

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  11. Organic solute carrier partner 1 (OSCP1) is known to facilitate the transport of various organic solutes into cells and reported to play a role in cell growth and cell differentiation. Moreover, OSCP1 is known...

    Authors: Nguyen Tho Huu, Hideki Yoshida, Takanari Umegawachi, Seiji Miyata and Masamitsu Yamaguchi

    Citation: BMC Biochemistry 2014 15:11

    Content type: Research article

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  12. Calciotropic hormones were thought to facilitate calcium transfer through active transcellular or passive paracellular pathway for calcium homeostasis. While calcium transport proteins such as CaBP-28 k, TRPV5...

    Authors: Inho Hwang, Eui-Ju Hong, Hyun Yang, Hong-Seok Kang, Changhwan Ahn, Beum-Soo An and Eui-Bae Jeung

    Citation: BMC Biochemistry 2014 15:6

    Content type: Research article

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  13. Autophagy is a cellular response to intracellular pathogens including mycobacteria and is induced by the direct inhibitors of mammalian target of Rapamycin (mTOR), a major negative regulator of autophagy. Auto...

    Authors: Alfred J Zullo, Kristen L Jurcic Smith and Sunhee Lee

    Citation: BMC Biochemistry 2014 15:4

    Content type: Research article

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  14. Transforming growth factor-betas (TGF-βs), including beta2 (TGF-β2), constitute a superfamily of multifunctional cytokines with important implications in morphogenesis, cell differentiation and tissue remodeli...

    Authors: Yan-Bin XiYang, Fang Wang, Bao-Jiang Qian, Ling You, Bing-Tuan Lu, Wei Zhang, Xiong-Zhi Quan, Wen-Ping Ge, Su Liu, Lian-Feng Zhang and Ting-Hua Wang

    Citation: BMC Biochemistry 2013 14:21

    Content type: Research article

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  15. Non-steroidal anti-inflammatory drugs (NSAIDs) —aspirin, naproxen, nimesulide, and piroxicam— lowered activation of type II cAMP-dependent protein kinase A (PKA-II) in isolated rat adipocytes, decreasing adren...

    Authors: Héctor Vázquez-Meza, Martha Zentella de Piña, Juan Pablo Pardo, Héctor Riveros-Rosas, Rafael Villalobos-Molina and Enrique Piña

    Citation: BMC Biochemistry 2013 14:13

    Content type: Research article

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  16. The androgen receptor (AR) is a member of the nuclear receptor (NR) superfamily of ligand-inducible DNA transcription factors, and is the major mediator of male sexual development, prostate growth and the path...

    Authors: Daniel Abankwa, Susan M Millard, Nick Martel, Catherine S Choong, Miao Yang, Lisa M Butler, Grant Buchanan, Wayne D Tilley, Nobuhide Ueki, Michael J Hayman and Gary M Leong

    Citation: BMC Biochemistry 2013 14:10

    Content type: Research article

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  17. Receptor tyrosine kinases (RTKs) are crucial components of signal transduction systems in multicellular animals. Surprisingly, numerous RTKs have been identified in the genomes of unicellular choanoflagellates...

    Authors: Kira P Schultheiss, Barbara P Craddock, Michael Tong, Markus Seeliger and W Todd Miller

    Citation: BMC Biochemistry 2013 14:4

    Content type: Research article

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  18. Presenilin-1 (PS1) is a transmembrane protein first discovered because of its association with familial Alzheimer’s disease. Mice with null mutations in PS1 die shortly after birth exhibiting multiple CNS and ...

    Authors: Rita De Gasperi, Miguel A Gama Sosa and Gregory A Elder

    Citation: BMC Biochemistry 2012 13:28

    Content type: Research article

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  19. Nasopharyngeal carcinoma (NPC) has a high metastatic feature. N,N-Dinitrosopiperazine (DNP) is involved in NPC metastasis, but its mechanism is not clear. The aim of this study is to reveal the pathogenesis of D...

    Authors: Yuejin Li, Na Liu, Damao Huang, Zhenlin Zhang, Zhengke Peng, Chaojun Duan, Xiaowei Tang, Gongjun Tan, Guangrong Yan, Wenhua Mei and Faqing Tang

    Citation: BMC Biochemistry 2012 13:25

    Content type: Research article

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  20. Phosphatase of regenerating liver-3 (PRL-3 or PTP4A3) has been implicated in controlling cancer cell proliferation, motility, metastasis, and angiogenesis. Deregulated expression of PRL-3 is highly correlated ...

    Authors: Wei Tian, Like Qu, Lin Meng, Caiyun Liu, Jian Wu and Chengchao Shou

    Citation: BMC Biochemistry 2012 13:22

    Content type: Research article

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  21. STAT1 is an essential transcription factor for interferon-γ-mediated gene responses. A distinct sumoylation consensus site (ψKxE) 702IKTE705 is localized in the C-terminal region of STAT1, where Lys703 is a targe...

    Authors: Juha Grönholm, Sari Vanhatupa, Daniela Ungureanu, Jouni Väliaho, Tuomo Laitinen, Jarkko Valjakka and Olli Silvennoinen

    Citation: BMC Biochemistry 2012 13:20

    Content type: Research article

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  22. Bird species show a high degree of variation in the composition of their preen gland waxes. For instance, galliform birds like chicken contain fatty acid esters of 2,3-alkanediols, while Anseriformes like goose o...

    Authors: Eva-Maria Biester, Janine Hellenbrand, Jens Gruber, Mats Hamberg and Margrit Frentzen

    Citation: BMC Biochemistry 2012 13:4

    Content type: Research article

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  23. ATP-binding cassette transporter A1 (ABCA1) mediates the lipidation of exchangeable apolipoproteins, the rate-limiting step in the formation of high density lipoproteins (HDL). We previously demonstrated that ...

    Authors: Mohammad A Hossain, Sereyrath Ngeth, Teddy Chan, Michael N Oda and Gordon A Francis

    Citation: BMC Biochemistry 2012 13:1

    Content type: Research article

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  24. Birds clean and lubricate their feathers with waxes that are produced in the uropygial gland, a holocrine gland located on their back above the tail. The type and the composition of the secreted wax esters are...

    Authors: Janine Hellenbrand, Eva-Maria Biester, Jens Gruber, Mats Hamberg and Margrit Frentzen

    Citation: BMC Biochemistry 2011 12:64

    Content type: Research article

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    1.595 - 2-year Impact Factor
    1.515 - 5-year Impact Factor
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