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  1. Nasopharyngeal carcinoma (NPC) has a high metastatic feature. N,N-Dinitrosopiperazine (DNP) is involved in NPC metastasis, but its mechanism is not clear. The aim of this study is to reveal the pathogenesis of D...

    Authors: Yuejin Li, Na Liu, Damao Huang, Zhenlin Zhang, Zhengke Peng, Chaojun Duan, Xiaowei Tang, Gongjun Tan, Guangrong Yan, Wenhua Mei and Faqing Tang

    Citation: BMC Biochemistry 2012 13:25

    Content type: Research article

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  2. Phosphatase of regenerating liver-3 (PRL-3 or PTP4A3) has been implicated in controlling cancer cell proliferation, motility, metastasis, and angiogenesis. Deregulated expression of PRL-3 is highly correlated ...

    Authors: Wei Tian, Like Qu, Lin Meng, Caiyun Liu, Jian Wu and Chengchao Shou

    Citation: BMC Biochemistry 2012 13:22

    Content type: Research article

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  3. Methionine (Met) residues in proteins can be readily oxidized by reactive oxygen species to Met sulfoxide (MetO). MetO is a promising physiological marker of oxidative stress and its inefficient repair by MetO...

    Authors: Xinwen Liang, Alaattin Kaya, Yan Zhang, Dung Tien Le, Deame Hua and Vadim N Gladyshev

    Citation: BMC Biochemistry 2012 13:21

    Content type: Research article

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  4. STAT1 is an essential transcription factor for interferon-γ-mediated gene responses. A distinct sumoylation consensus site (ψKxE) 702IKTE705 is localized in the C-terminal region of STAT1, where Lys703 is a targe...

    Authors: Juha Grönholm, Sari Vanhatupa, Daniela Ungureanu, Jouni Väliaho, Tuomo Laitinen, Jarkko Valjakka and Olli Silvennoinen

    Citation: BMC Biochemistry 2012 13:20

    Content type: Research article

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  5. Streptococcus pneumoniae expresses three distinct sialidases, NanA, NanB, and NanC, that are believed to be key virulence factors and thus, potential important drug targets. We previously reported that the three ...

    Authors: Jasvinder Kaur Hayre, Guogang Xu, Luisa Borgianni, Garry L Taylor, Peter W Andrew, Jean-Denis Docquier and Marco R Oggioni

    Citation: BMC Biochemistry 2012 13:19

    Content type: Methodology article

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  6. Mutations to the TSC1 and TSC2 genes cause the disease tuberous sclerosis complex. The TSC1 and TSC2 gene products form a protein complex that integrates multiple metabolic signals to regulate the activity of the...

    Authors: Marianne Hoogeveen-Westerveld, Leontine van Unen, Ans van den Ouweland, Dicky Halley, Andre Hoogeveen and Mark Nellist

    Citation: BMC Biochemistry 2012 13:18

    Content type: Research article

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  7. The molecular basis of the increased susceptibility of steatotic livers to warm ischemia/reperfusion (I/R) injury during transplantation remains undefined. Animal model for warm I/R injury was induced in obese...

    Authors: Venkataswarup Tiriveedhi, Kendra D Conzen, Jane Liaw-Conlin, Gundumi Upadhya, James Malone, R Reid Townsend, Robnet Kerns, Jianluo Jia, Krista Csontos, Sabarinathan Ramachandran, Thallachallour Mohanakumar, Christopher D Anderson and William C Chapman

    Citation: BMC Biochemistry 2012 13:17

    Content type: Research article

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  8. Protein-protein interactions are at the basis of many cellular processes, and they are also involved in the interaction between pathogens and their host(s). Many intracellular pathogenic bacteria translocate p...

    Authors: Bernard Nkengfac, Jenny Pouyez, Emilie Bauwens, Jean Vandenhaute, Jean-Jacques Letesson, Johan Wouters and Xavier De Bolle

    Citation: BMC Biochemistry 2012 13:16

    Content type: Research article

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  9. Epitope tags and fluorescent fusion proteins have become indispensable molecular tools for studies in the fields of biochemistry and cell biology. The knowledge collected on the subdomain organization of the t...

    Authors: Simona Morlacchi, Francesca Sciandra, Maria Giulia Bigotti, Manuela Bozzi, Wolfgang Hübner, Antonio Galtieri, Bruno Giardina and Andrea Brancaccio

    Citation: BMC Biochemistry 2012 13:14

    Content type: Research article

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  10. Thymidine kinase 1 (TK1) is a salvage enzyme involved in DNA precursor synthesis, and its expression is proliferation dependent. A serum form of TK1 has been used as a biomarker in human medicine for many year...

    Authors: Sharif Hanan, Kiran Kumar Jagarlamudi, Wang Liya, He Ellen and Eriksson Staffan

    Citation: BMC Biochemistry 2012 13:12

    Content type: Research article

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  11. The Gtr1 protein of Saccharomyces cerevisiae is a member of the RagA subfamily of the Ras-like small GTPase superfamily. Gtr1 has been implicated in various cellular processes. Particularly, the Switch regions in...

    Authors: Palanivelu Sengottaiyan, Cornelia Spetea, Jens O Lagerstedt, Dieter Samyn, Michael Andersson, Lorena Ruiz-Pavón and Bengt L Persson

    Citation: BMC Biochemistry 2012 13:11

    Content type: Research article

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  12. Nuclear factor kappa B (NF-κB) is a key transcription factor that plays a crucial role in host survival during infection by pathogens. Therefore, it has been a priority of many pathogens to manipulate the cell...

    Authors: Milan Surjit, Bhavna Varshney and Sunil K Lal

    Citation: BMC Biochemistry 2012 13:7

    Content type: Research article

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  13. CELF/Bruno-like proteins play multiple roles, including the regulation of alternative splicing and translation. These RNA-binding proteins contain two RNA recognition motif (RRM) domains at the N-terminus and ...

    Authors: Hitoshi Suzuki, Makoto Takeuchi, Ayumu Sugiyama, AHM Khurshid Alam, Luyen Thi Vu, Yoshiharu Sekiyama, Hieu Chi Dam, Shin-ya Ohki and Toshifumi Tsukahara

    Citation: BMC Biochemistry 2012 13:6

    Content type: Research article

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  14. A group of abundant proteins of ~30 kDa is synthesized in silkworm larval peripheral fat body (PPFB) tissues and transported into the open circulatory system (hemolymph) in a time-depended fashion to be eventu...

    Authors: Britto Cathrin Pakkianathan, Nitin Kumar Singh, Muthukalingan Krishnan and Simone König

    Citation: BMC Biochemistry 2012 13:5

    Content type: Research article

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  15. Bird species show a high degree of variation in the composition of their preen gland waxes. For instance, galliform birds like chicken contain fatty acid esters of 2,3-alkanediols, while Anseriformes like goose o...

    Authors: Eva-Maria Biester, Janine Hellenbrand, Jens Gruber, Mats Hamberg and Margrit Frentzen

    Citation: BMC Biochemistry 2012 13:4

    Content type: Research article

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  16. Enzymatic allergens of storage mites that contaminate stored food products are poorly characterized. We describe biochemical and immunological properties of the native alpha-amylase allergen Aca s 4 from Acarus s...

    Authors: Jana Pytelková, Martin Lepšík, Miloslav Šanda, Pavel Talacko, Lucie Marešová and Michael Mareš

    Citation: BMC Biochemistry 2012 13:3

    Content type: Research article

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  17. ATP-binding cassette transporter A1 (ABCA1) mediates the lipidation of exchangeable apolipoproteins, the rate-limiting step in the formation of high density lipoproteins (HDL). We previously demonstrated that ...

    Authors: Mohammad A Hossain, Sereyrath Ngeth, Teddy Chan, Michael N Oda and Gordon A Francis

    Citation: BMC Biochemistry 2012 13:1

    Content type: Research article

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  18. Conjugation of human and animal hemoglobins with polyethylene glycol has been widely explored as a means to develop blood substitutes, a novel pharmaceutical class to be used in surgery or emergency medicine. ...

    Authors: Daniela Coppola, Stefano Bruno, Luca Ronda, Cristiano Viappiani, Stefania Abbruzzetti, Guido di Prisco, Cinzia Verde and Andrea Mozzarelli

    Citation: BMC Biochemistry 2011 12:66

    Content type: Research article

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  19. Nucleotide pyrophosphatase/phosphodiesterase 7 (NPP7) is the only member of the mammalian NPP enzyme family that has been confirmed to act as a sphingomyelinase, hydrolyzing sphingomyelin (SM) to form phosphoc...

    Authors: Abby L Parrill, Irene W Wanjala, Truc Chi T Pham and Daniel L Baker

    Citation: BMC Biochemistry 2011 12:65

    Content type: Research article

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  20. Birds clean and lubricate their feathers with waxes that are produced in the uropygial gland, a holocrine gland located on their back above the tail. The type and the composition of the secreted wax esters are...

    Authors: Janine Hellenbrand, Eva-Maria Biester, Jens Gruber, Mats Hamberg and Margrit Frentzen

    Citation: BMC Biochemistry 2011 12:64

    Content type: Research article

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  21. The TaqII enzyme is a member of the Thermus sp. enzyme family that we propounded previously within Type IIS restriction endonucleases, containing related thermophilic bifunctional endonucleases-methyltransferases...

    Authors: Agnieszka Żylicz-Stachula, Olga Żołnierkiewicz, Katarzyna Śliwińska, Joanna Jeżewska-Frąckowiak and Piotr M Skowron

    Citation: BMC Biochemistry 2011 12:62

    Content type: Research article

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  22. Caseinolytic proteases (ClpPs) are barrel-shaped self-compartmentalized peptidases involved in eliminating damaged or short-lived regulatory proteins. The Mycobacterium tuberculosis (MTB) genome contains two gene...

    Authors: Nadia Benaroudj, Bertrand Raynal, Marika Miot and Miguel Ortiz-Lombardia

    Citation: BMC Biochemistry 2011 12:61

    Content type: Research article

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  23. Pharmacological thrombolysis with streptokinase, urokinase or tissue activator of plasminogen (t-PA), and mechanical interventions are frequently used in the treatment of both arterial and venous thrombotic di...

    Authors: Eugene A Cherniavsky, Igor S Strakha, Igor E Adzerikho and Vladimir M Shkumatov

    Citation: BMC Biochemistry 2011 12:60

    Content type: Research article

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  24. The Gram-negative bacterium Haemophilus influenzae is a glutathione auxotroph and acquires the redox-active tripeptide by import. The dedicated glutathione transporter belongs to the ATP-binding cassette (ABC)-tr...

    Authors: Bjorn Vergauwen, Ruben Van der Meeren, Ann Dansercoer and Savvas N Savvides

    Citation: BMC Biochemistry 2011 12:59

    Content type: Research article

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  25. Botulism is caused by botulinum neurotoxins (BoNTs), extremely toxic proteins which can induce respiratory failure leading to long-term intensive care or death. Treatment for botulism includes administration o...

    Authors: Suzanne R Kalb, Wanda I Santana, Isin N Geren, Consuelo Garcia-Rodriguez, Jianlong Lou, Theresa J Smith, James D Marks, Leonard A Smith, James L Pirkle and John R Barr

    Citation: BMC Biochemistry 2011 12:58

    Content type: Research article

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  26. PPP1R6 is a protein phosphatase 1 glycogen-targeting subunit (PP1-GTS) abundant in skeletal muscle with an undefined metabolic control role. Here PPP1R6 effects on myotube glycogen metabolism, particle size an...

    Authors: Marta Montori-Grau, Maria Guitart, Cèlia García-Martínez, Anna Orozco and Anna Maria Gómez-Foix

    Citation: BMC Biochemistry 2011 12:57

    Content type: Research article

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  27. Staphylococcus aureus is a human pathogen that produces extracellular adenosine to evade clearance by the host immune system, an activity attributed to the 5'-nucleotidase activity of adenosine synthase (AdsA). I...

    Authors: Vilasack Thammavongsa, Olaf Schneewind and Dominique M Missiakas

    Citation: BMC Biochemistry 2011 12:56

    Content type: Research article

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  28. We have previously identified a locus on human chromosome 20q13.1, encompassing related genes of postulated WFDC-type protease inhibitors and semen coagulum proteins. Three of the genes with WFDC motif also co...

    Authors: Adam Clauss, Margareta Persson, Hans Lilja and Åke Lundwall

    Citation: BMC Biochemistry 2011 12:55

    Content type: Research article

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  29. Striatin, a putative protein phosphatase 2A (PP2A) B-type regulatory subunit, is a multi-domain scaffolding protein that has recently been linked to several diseases including cerebral cavernous malformation (...

    Authors: Johnthan Gordon, Juyeon Hwang, Karma J Carrier, Candace A Jones, Quiana L Kern, Carlos S Moreno, Richard H Karas and David C Pallas

    Citation: BMC Biochemistry 2011 12:54

    Content type: Research article

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  30. Hemojuvelin (HJV) is one of essential components for expression of hepcidin, a hormone which regulates iron transport. HJV is mainly expressed in muscle and liver, and processing of HJV in both tissues is simi...

    Authors: Yuzo Fujikura, Jan Krijt and Emanuel Nečas

    Citation: BMC Biochemistry 2011 12:52

    Content type: Research article

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  31. Steroid Receptor coactivator 3(SRC3) is an oncogene and a member of the SRC family of nuclear receptor coactivator proteins that mediate the transcriptional effects of nuclear hormone receptors as well as othe...

    Authors: Dale Corkery, Gobi Thillainadesan, Niamh Coughlan, Ryan D Mohan, Majdina Isovic, Marc Tini and Joseph Torchia

    Citation: BMC Biochemistry 2011 12:50

    Content type: Research article

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  32. Epigenetic reading domains are involved in the regulation of gene expression and chromatin state by interacting with histones in a post-translational modification specific manner. A detailed knowledge of the t...

    Authors: Ina Bock, Srikanth Kudithipudi, Raluca Tamas, Goran Kungulovski, Arunkumar Dhayalan and Albert Jeltsch

    Citation: BMC Biochemistry 2011 12:48

    Content type: Research article

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  33. Restriction endonucleases are widely applied in recombinant DNA technology. Among them, enzymes of class IIS, which cleave DNA beyond recognition sites, are especially useful. We use BsaI enzyme for the pinpoi...

    Authors: Ireneusz Sobolewski, Katarzyna Polska, Agnieszka Żylicz-Stachula, Joanna Jeżewska-Frąckowiak, Janusz Rak and Piotr Skowron

    Citation: BMC Biochemistry 2011 12:47

    Content type: Methodology article

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  34. Pathogens depend on peptidase activities to accomplish many physiological processes, including interaction with their hosts, highlighting parasitic peptidases as potential drug targets. In this study, a major ...

    Authors: Gloria Cadavid-Restrepo, Thiago S Gastardelo, Eric Faudry, Hugo de Almeida, Izabela MD Bastos, Raquel S Negreiros, Meire M Lima, Teresa C Assumpção, Keyla C Almeida, Michel Ragno, Christine Ebel, Bergmann M Ribeiro, Carlos R Felix and Jaime M Santana

    Citation: BMC Biochemistry 2011 12:46

    Content type: Research article

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  35. Large surface loops contained within compact protein structures and not involved in catalytic process have been proposed as preferred regions for protein family evolution. These loops are subjected to lower se...

    Authors: Edoardo Giacopuzzi, Sergio Barlati, Augusto Preti, Bruno Venerando, Eugenio Monti, Giuseppe Borsani and Roberto Bresciani

    Citation: BMC Biochemistry 2011 12:45

    Content type: Research article

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  36. Acyl-acyl carrier protein thioesterases (acyl-ACP TEs) catalyze the hydrolysis of the thioester bond that links the acyl chain to the sulfhydryl group of the phosphopantetheine prosthetic group of ACP. This re...

    Authors: Fuyuan Jing, David C Cantu, Jarmila Tvaruzkova, Jay P Chipman, Basil J Nikolau, Marna D Yandeau-Nelson and Peter J Reilly

    Citation: BMC Biochemistry 2011 12:44

    Content type: Research article

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  37. The major Dengue virus vector Aedes aegypti requires nutrients obtained from blood meal proteins to complete the gonotrophic cycle. Although bioinformatic analyses of Ae. aegypti midgut serine proteases have prov...

    Authors: Alberto A Rascón Jr, Johnathon Gearin, Jun Isoe and Roger L Miesfeld

    Citation: BMC Biochemistry 2011 12:43

    Content type: Research article

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