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  1. This study was aimed primarily at testing in the liver of brown trout (Salmo trutta) spectrophotometric methods previously used to measure the activities of catalase and hydrogen peroxide producing oxidases in ma...

    Authors: Maria João Rocha, Eduardo Rocha, Albina D Resende and Alexandre Lobo-da-Cunha
    Citation: BMC Biochemistry 2003 4:2
  2. Pigment epithelium-derived factor (PEDF) has binding affinity for cell-surface receptors in retinoblastoma cells and for glycosaminoglycans. We investigated the effects of glycosaminoglycans on PEDF-receptor i...

    Authors: Elena M Alberdi, John E Weldon and S Patricia Becerra
    Citation: BMC Biochemistry 2003 4:1
  3. The cytoplasmic tyrosine kinase, Src, has been found to play a crucial role in VEGF (vascular endothelial growth factor) – dependent vascular permeability involved in angiogenesis. The two main VEGFRs present ...

    Authors: Mary T Chou, Jing Wang and Donald J Fujita
    Citation: BMC Biochemistry 2002 3:32
  4. The 85-kDa cytosolic phospholipase A2 (cPLA2) mediates arachidonic acid (AA) release in MDCK cells. Although calcium and mitogen-activated protein kinases regulate cPLA2, the correlation of cPLA2 translocation an...

    Authors: John H Evans, Daniel J Fergus and Christina C Leslie
    Citation: BMC Biochemistry 2002 3:30
  5. Three macromolecular assemblages, the lid complex of the proteasome, the COP9-Signalosome (CSN) and the eIF3 complex, all consist of multiple proteins harboring MPN and PCI domains. Up to now, no specific func...

    Authors: Vered Maytal-Kivity, Noa Reis, Kay Hofmann and Michael H Glickman
    Citation: BMC Biochemistry 2002 3:28
  6. Soluble guanylyl cyclase (sGC) is the main receptor for nitric oxide (NO) when the latter is produced at low concentrations. This enzyme exists mainly as a heterodimer consisting of one α and one β subunit and...

    Authors: Rut Ferrero and Magdalena Torres
    Citation: BMC Biochemistry 2002 3:26
  7. The cyclic AMP specific phosphodiesterase, PDE4D5 interacts with the β-propeller protein RACK1 to form a signaling scaffold complex in cells. Two-hybrid analysis of truncation and mutant constructs of the uniq...

    Authors: Graeme B Bolger, Angela McCahill, Stephen J Yarwood, Michael R Steele, Jim Warwicker and Miles D Houslay
    Citation: BMC Biochemistry 2002 3:24
  8. The S. cerevisiae origin recognition complex binds to the ARS consensus sequence in an ATP dependent fashion. Recently, the yeast Cdc6 has been reported to have DNA binding activity. Conservation of replication p...

    Authors: Suman K Dhar, Neelima Mondal, Rajesh K Soni and Gauranga Mukhopadhyay
    Citation: BMC Biochemistry 2002 3:23
  9. SCF ubiquitin ligases share the core subunits cullin 1, SKP1, and HRT1/RBX1/ROC1, which associate with different F-box proteins. F-box proteins bind substrates following their phosphorylation upon stimulation ...

    Authors: Volker Seibert, Corinna Prohl, Ida Schoultz, Edward Rhee, Rebecca Lopez, Kareem Abderazzaq, Chunshui Zhou and Dieter A Wolf
    Citation: BMC Biochemistry 2002 3:22
  10. Acetylcholinesterase is irreversibly inhibited by organophosphate and carbamate insecticides allowing its use for residue detection with biosensors. Drosophila acetylcholinesterase is the most sensitive enzyme kn...

    Authors: Isabelle Fremaux, Serge Mazères, Andrée Brisson-Lougarre, Muriel Arnaud, Caroline Ladurantie and Didier Fournier
    Citation: BMC Biochemistry 2002 3:21
  11. The human genome contains at least 18 genes for Nudix hydrolase enzymes. Many have similar functions to one another. In order to understand their roles in cell physiology, these proteins must be characterised.

    Authors: Nick R Leslie, Alexander G McLennan and Stephen T Safrany
    Citation: BMC Biochemistry 2002 3:20
  12. HIV-1 RT is a heterodimeric enzyme, comprising of the p66 and p51 subunits. Earlier, we have shown that the β7-β8 loop of p51 is a key structural element for RT dimerization (Pandey et al., Biochemistry 40: 95...

    Authors: Pradeep K Pandey, Neerja Kaushik, Kamalendra Singh, Bechan Sharma, Alok K Upadhyay, Suriender Kumar, Dylan Harris and Virendra N Pandey
    Citation: BMC Biochemistry 2002 3:18
  13. Lerisetron, a competitive serotonin type 3 receptor (5-HT3R) antagonist, contains five functional groups capable of interacting with amino acids in the 5-HT3R binding site. Site directed mutagenesis studies of th...

    Authors: Padmavati Venkataraman, Prasad Joshi, Srinivasan P Venkatachalan, Mani Muthalagi, Harish S Parihar, Karen S Kirschbaum and Marvin K Schulte
    Citation: BMC Biochemistry 2002 3:16
  14. The serotonin type 3 receptor (5-HT3R) is a member of a superfamily of ligand gated ion channels. All members of this family share a large degree of sequence homology and presumably significant structural similar...

    Authors: Padmavati Venkataraman, Srinivasan P Venkatachalan, Prasad R Joshi, Mani Muthalagi and Marvin K Schulte
    Citation: BMC Biochemistry 2002 3:15
  15. Expression profiling holds great promise for rapid host genome functional analysis. It is plausible that host expression profiling in an infection could serve as a universal phenotype in virally infected cells...

    Authors: Cynthia de la Fuente, Francisco Santiago, Longwen Deng, Carolyne Eadie, Irene Zilberman, Kylene Kehn, Anil Maddukuri, Shanese Baylor, Kaili Wu, Chee Gun Lee, Anne Pumfery and Fatah Kashanchi
    Citation: BMC Biochemistry 2002 3:14
  16. Profilin is a small cytoskeletal protein which interacts with actin, proline-rich proteins and phosphatidylinositol 4,5-bisphosphate (PI(4,5)-P2). Crystallography, NMR and mutagenesis of vertebrate profilins have...

    Authors: Anja Lambrechts, Veronique Jonckheere, Daisy Dewitte, Joel Vandekerckhove and Christophe Ampe
    Citation: BMC Biochemistry 2002 3:12
  17. Dictyostelium cells exhibit an unusual stress response as they protect themselves against hyperosmotic stress. Cytoskeletal proteins are recruited from the cytosolic pool to the cell cortex, thereby reinforcing i...

    Authors: Tanja Pintsch, Hans Zischka and Stephan C Schuster
    Citation: BMC Biochemistry 2002 3:10
  18. Monolysocardiolipin acyltransferase (MLCL AT) catalyzes the acylation of monolysocardiolipin to cardiolipin in mammalian tissues. We previously reported that cardiac cardiolipin levels, MLCL AT and cardiolipin...

    Authors: William A Taylor, Fred Y Xu, Brian J Ma, Thomas C Mutter, Vernon W Dolinsky and Grant M Hatch
    Citation: BMC Biochemistry 2002 3:9
  19. Thiamine diphosphate (ThDP) is the active form of thiamine, and it serves as a cofactor for several enzymes, both cytosolic and mitochondrial. Isolated mitochondria have been shown to take up thiamine yet thia...

    Authors: Qilin Song and Charles K Singleton
    Citation: BMC Biochemistry 2002 3:8
  20. Within the family of green fluorescent protein (GFP) homologs, one can mark two main groups, specifically, fluorescent proteins (FPs) and non-fluorescent or chromoproteins (CPs). Structural background of diffe...

    Authors: Maria E Bulina, Dmitry M Chudakov, Nikolay N Mudrik and Konstantin A Lukyanov
    Citation: BMC Biochemistry 2002 3:7
  21. The metallo-β-lactamases are Zn(II)-containing enzymes that hydrolyze the β-lactam bond in penicillins, cephalosporins, and carbapenems and are involved in bacterial antibiotic resistance. There are at least 2...

    Authors: Anne L Carenbauer, James D Garrity, Gopal Periyannan, Robert B Yates and Michael W Crowder
    Citation: BMC Biochemistry 2002 3:4
  22. Several Trichoderma strains have been reported to be effective in controlling plant diseases, and the action of fungal hydrolytic enzymes has been considered as the main mechanism involved in the antagonistic pro...

    Authors: Janice L De Marco and Carlos Roberto Felix
    Citation: BMC Biochemistry 2002 3:3
  23. In humans, there are four alkaline phosphatases, and each form exibits a characteristic pattern of tissue distribution. The availability of an easy method to reveal their activity has resulted in large amount ...

    Authors: Colette C Denier, Andrée A Brisson-Lougarre, Ghislaine G Biasini, Jean J Grozdea and Didier D Fournier
    Citation: BMC Biochemistry 2002 3:2
  24. Nitric oxide (NO) and oxygen free-radicals play an important part in the destruction of beta-cells in auto- immune diabetes although the precise mechanism of interaction is still not known. This study was desi...

    Authors: Donovan McGrowder, Dalip Ragoobirsingh and Tara Dasgupta
    Citation: BMC Biochemistry 2002 3:1
  25. Most test systems for acetylcholinesterase activity (E.C. are using toxic inhibitors (BW284c51 and iso-OMPA) to distinguish the enzyme from butyrylcholinesterase (E.C. which occurs simultaneo...

    Authors: Wolfram H Kluge, Harald H Kluge, Heike I Bauer, Stefan Pietsch, Jens Anders and Rudolf A Venbrocks
    Citation: BMC Biochemistry 2001 2:17
  26. Scorpion venom contains insect and mammal selective toxins. We investigated the venom of the South Indian red scorpion, Mesobuthus tamulus for the purpose of identifying potent insecticidal peptide toxins.

    Authors: Rajendra Wudayagiri, Bora Inceoglu, Rafael Herrmann, Maher Derbel, Prabhakara V Choudary and Bruce D Hammock
    Citation: BMC Biochemistry 2001 2:16
  27. Free radicals generated in biological systems by cigarette smoke (CS) inhalation can cause oxidative stress in tissues, resulting in lipid peroxidation (LPO). In view of the antioxidant properties of α-tocophe...

    Authors: Ashwani Koul, Vipin Bhatia and MP Bansal
    Citation: BMC Biochemistry 2001 2:14
  28. To better understand the molecular interactions of Bt toxins with non-target insects, we have examined the real-time binding specificity and affinity of Cry1 toxins to native silkworm (Bombyx mori) midgut recepto...

    Authors: Jeremy L Jenkins and Donald H Dean
    Citation: BMC Biochemistry 2001 2:12
  29. The CD98 (4F2, FRP-1) is a widely expressed cell surface protein heterodimer composed of a glycosylated heavy chain and a non-glycosylated light chain. Originally described as a T cell activation antigen, it w...

    Authors: Tatiana V Kolesnikova, Brian A Mannion, Fedor Berditchevski and Martin E Hemler
    Citation: BMC Biochemistry 2001 2:10
  30. The hydrolysis of ATP and ADP by ecto-nucleoside triphosphate diphosphohydrolase 1 (CD39) requires divalent cations, like Ca2+ and Mg2+. In spite of considerable work, it is not clear whether divalent cations bin...

    Authors: Wei Chen and Guido Guidotti
    Citation: BMC Biochemistry 2001 2:9
  31. The function of the fission yeast cullins Pcu1p and Pcu4p requires modification by the ubiquitin-related peptide Ned8p. A recent report by Lyapina et al. shows that the COP9/signalosome (CSN), a multifunctional e...

    Authors: Chunshui Zhou, Volker Seibert, Rory Geyer, Edward Rhee, Svetlana Lyapina, Greg Cope, Raymond J Deshaies and Dieter A Wolf
    Citation: BMC Biochemistry 2001 2:7
  32. Green Fluorescent Protein (GFP) cloned from jellyfish Aequorea victoria and its homologs from corals Anthozoa have a great practical significance as in vivo markers of gene expression. Also, they are an interesti...

    Authors: Nadya G Gurskaya, Alexander P Savitsky, Yurii G Yanushevich, Sergey A Lukyanov and Konstantin A Lukyanov
    Citation: BMC Biochemistry 2001 2:6
  33. Ca2+-ATPases of endoplasmic reticulum (SERCAs) are responsible for maintenance of the micro- to millimolar Ca2+ ion concentrations within the endoplasmic reticulum (ER) of eukaryotic cells. This intralumenal Ca2+

    Authors: Annette Højmann Larsen, Aase Frandsen and Marek Treiman
    Citation: BMC Biochemistry 2001 2:4