Volume 9 Supplement 1

Ubiquitin-Proteasome System in Disease Part 2


Edited by John Mayer and Rob Layfield

  1. Review

    Targeting the UPS as therapy in multiple myeloma

    The coordinated regulation of cellular protein synthesis and degradation is essential for normal cellular functioning. The ubiquitin proteasome system mediates the intracellular protein degradation that is req...

    Dharminder Chauhan, Giada Bianchi and Kenneth C Anderson

    BMC Biochemistry 2008 9(Suppl 1):S1

    Published on: 21 October 2008

  2. Review

    The UPS: a promising target for breast cancer treatment

    During the past decade, progress in endocrine therapy and the use of trastuzumab has significantly contributed to the decline in breast cancer mortality for hormone receptor-positive and ERBB2 (HER2)-positive ...

    Ko Sato, Eeson Rajendra and Tomohiko Ohta

    BMC Biochemistry 2008 9(Suppl 1):S2

    Published on: 21 October 2008

  3. Review

    Deubiquitylating enzymes and disease

    Deubiquitylating enzymes (DUBs) can hydrolyze a peptide, amide, ester or thiolester bond at the C-terminus of UBIQ (ubiquitin), including the post-translationally formed branched peptide bonds in mono- or mult...

    Shweta Singhal, Matthew C Taylor and Rohan T Baker

    BMC Biochemistry 2008 9(Suppl 1):S3

    Published on: 21 October 2008

  4. Review

    HPV E6, E6AP and cervical cancer

    Every year, approximately 470,000 new cases of cervical cancer are diagnosed and approximately 230,000 women worldwide die of the disease, with the majority (~80%) of these cases and deaths occurring in develo...

    Sylvie Beaudenon and Jon M Huibregtse

    BMC Biochemistry 2008 9(Suppl 1):S4

    Published on: 21 October 2008

  5. Review

    Role of the UPS in Liddle syndrome

    Hypertension is a serious medical problem affecting a large population worldwide. Liddle syndrome is a hereditary form of early onset hypertension caused by mutations in the epithelial Na+ channel (ENaC). The mut...

    Daniela Rotin

    BMC Biochemistry 2008 9(Suppl 1):S5

    Published on: 21 October 2008

  6. Review

    The UPS in diabetes and obesity

    Type 2 diabetes is caused by defects in both insulin signaling and insulin secretion. Though the role of the ubiquitin proteasome system (UPS) in the pathogenesis of type 2 diabetes remains largely unexplored,...

    Simon S Wing

    BMC Biochemistry 2008 9(Suppl 1):S6

    Published on: 21 October 2008

  7. Review

    The ubiquitin system, disease, and drug discovery

    The ubiquitin system of protein modification has emerged as a crucial mechanism involved in the regulation of a wide array of cellular processes. As our knowledge of the pathways in this system has grown, so h...

    Matthew D Petroski

    BMC Biochemistry 2008 9(Suppl 1):S7

    Published on: 21 October 2008