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BMC Biochemistry

Chemical biology

  1. Content type: Research article

    Antiproliferative factor (APF) is a sialoglycopeptide elevated in the urine of patients with interstitial cystitis—a chronic, painful bladder disease. APF inhibits the proliferation of normal bladder epithelia...

    Authors: Burzin Chavda, Jun Ling, Thomas Majernick and Sonia Lobo Planey

    Citation: BMC Biochemistry 2017 18:13

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  2. Content type: Research article

    Protein tyrosine phosphatases (PTPs) like dual specificity phosphatase 5 (DUSP5) and protein tyrosine phosphatase 1B (PTP1B) are drug targets for diseases that include cancer, diabetes, and vascular disorders ...

    Authors: Robert D. Bongard, Michael Lepley, Khushabu Thakur, Marat R. Talipov, Jaladhi Nayak, Rachel A. Jones Lipinski, Chris Bohl, Noreena Sweeney, Ramani Ramchandran, Rajendra Rathore and Daniel S. Sem

    Citation: BMC Biochemistry 2017 18:10

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  3. Content type: Research article

    Human tyrosine-protein phosphatase non-receptor type substrate 1α (SIRPA) is a surface marker identified in cardiomyocytes differentiated from human embryonic stem cells. Our objective was to determine if circ...

    Authors: Pranali Patel, Uros Kuzmanov and Seema Mital

    Citation: BMC Biochemistry 2016 17:17

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  4. Content type: Research article

    In drug discovery research, cell-based phenotypic screening is an essential method for obtaining potential drug candidates. Revealing the mechanism of action is a key step on the path to drug discovery. Howeve...

    Authors: Yasunori Fukuda, Osamu Sano, Kenichi Kazetani, Koji Yamamoto, Hidehisa Iwata and Junji Matsui

    Citation: BMC Biochemistry 2016 17:9

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  5. Content type: Research article

    Hydroxyl radical that has the highest reactivity among reactive oxygen species (ROS) is generated through l-tyrosine-tyrosinase reaction. Thus, the melanogenesis might induce oxidative stress in the skin. A rbuti...

    Authors: Mika Tada, Masahiro Kohno and Yoshimi Niwano

    Citation: BMC Biochemistry 2014 15:23

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  6. Content type: Research article

    Ethylene is one of the most used chemical monomers derived from non-renewable sources and we are investigating the possibility of producing it in yeast via the ethylene forming enzyme (EFE) from Pseudomonas syrin...

    Authors: Nina Johansson, Karl O Persson, Christer Larsson and Joakim Norbeck

    Citation: BMC Biochemistry 2014 15:22

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  7. Content type: Research article

    Dioscorea is a genus of flowering plants, and some Dioscorea species are known and used as a source for the steroidal sapogenin diosgenin. To screen potential resource from Dioscorea species and related medicinal...

    Authors: Tao Yi, Lan-Lan Fan, Hong-Li Chen, Guo-Yuan Zhu, Hau-Man Suen, Yi-Na Tang, Lin Zhu, Chu Chu, Zhong-Zhen Zhao and Hu-Biao Chen

    Citation: BMC Biochemistry 2014 15:19

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  8. Content type: Research article

    The cosmetics market has rapidly increased over the last years. For example, in 2011 it reached 242.8 billion US dollars, which was a 3.9% increase compared to 2010. There have been many recent trials aimed at...

    Authors: Dae-Hun Park, Dae Hyun Jung, Soo Jung Kim, Sung Han Kim and Kyung Mok Park

    Citation: BMC Biochemistry 2014 15:18

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  9. Content type: Research article

    Cytochrome c (Cyt c) is an apoptosis-initiating protein when released into the cytoplasm of eukaryotic cells and therefore a possible cancer drug candidate. Although proteins have been increasingly important a...

    Authors: Yamixa Delgado, Moraima Morales-Cruz, José Hernández-Román, Yashira Martínez and Kai Griebenow

    Citation: BMC Biochemistry 2014 15:16

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  10. Content type: Methodology article

    Carbohydrate-deficient transferrin (CDT) is a widely used alcohol biomarker. Because of the high prevalence of chronic alcohol abuse in many countries, CDT plays an important role in the areas of traffic, clin...

    Authors: Binbin Song, Jing Zhu, Jiong Wu, Chunyan Zhang, Beili Wang, Baishen Pan and Wei Guo

    Citation: BMC Biochemistry 2014 15:5

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  11. Content type: Research article

    The regulation of lipid biosynthesis is essential in photosynthetic eukaryotic cells. This regulation occurs during the direct synthesis of fatty acids and triacylglycerols (TAGs), as well as during other cont...

    Authors: Xiaodong Deng, Jiajia Cai and Xiaowen Fei

    Citation: BMC Biochemistry 2013 14:38

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  12. Content type: Research article

    Peroxidases are emerging as an important class of enzymes that can be used for the efficient degradation of organic pollutants. However, detailed studies identifying the various intermediates produced and the ...

    Authors: Liaquat Ali, Rowdha Algaithi, Hosam M Habib, Usama Souka, Muhammad A Rauf and S Salman Ashraf

    Citation: BMC Biochemistry 2013 14:35

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  13. Content type: Methodology article

    Huntington’s disease (HD) is a monogenic disorder caused by an aberrant expansion of CAG repeats in the huntingtin gene (HTT). Pathogenesis is associated with expression of the mutant (mHTT) protein in the CNS, w...

    Authors: Luisa Massai, Lara Petricca, Letizia Magnoni, Luca Rovetini, Salman Haider, Ralph Andre, Sarah J Tabrizi, Sigurd D Süssmuth, Bernhard G Landwehrmeyer, Andrea Caricasole, Giuseppe Pollio and Simonetta Bernocco

    Citation: BMC Biochemistry 2013 14:34

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  14. Content type: Research article

    The improvement of biomedical properties, e.g. biocompatibility, of poly(3-hydroxyalkanoates) (PHAs) by copolymerization is a promising trend in bioengineering. We used strain Azotobacter chroococcum 7B, an effec...

    Authors: Anton P Bonartsev, Sergey G Yakovlev, Irina I Zharkova, Arasha P Boskhomdzhiev, Dmitrii V Bagrov, Vera L Myshkina, Tatiana K Makhina, Elena P Kharitonova, Olga V Samsonova, Alexey V Feofanov, Vera V Voinova, Anton L Zernov, Yurii M Efremov, Garina A Bonartseva, Konstantin V Shaitan and Michail P Kirpichnikov

    Citation: BMC Biochemistry 2013 14:12

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