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Table 5 Clinical characteristics of TM6SF2 rs58542926 T carriers and non-carriers in each groupa

From: Association of TM6SF2 rs58542926 gene polymorphism with the risk of non-alcoholic fatty liver disease and colorectal adenoma in Chinese Han population

 

NAFLD

NAFLD&CRA

Carriers

(n = 13)

Non-carriers

(n = 188)

P value

Carriers

(n = 13)

Non-carriers

(n = 175)

P value

Age (yr)

53.80 ± 0.46

55.00 ± 0.51

0.534

54.90 ± 0.61

54.30 ± 0.49

0.411

BMI (kg/m2)

24.99 ± 1.36

23.95 ± 1.23

0.957

24.98 ± 1.98

26.12 ± 2.02

0.053

CAP (dB/m)

262.34 ± 32.65

239.11 ± 37.76

0.031

260.21 ± 22.52

240.46 ± 21.34

0.001

FPG (mmol/L)

4.89 ± 0.98

5.13 ± 0.12

0.163

5.21 ± 0.32

5.26 ± 0.79

0.341

TC (mmol/L)

5.01 ± 0.67

5.63 ± 0.83

0.352

4.80 ± 0.98

5.61 ± 0.78

0.013

TG (mmol/L)

1.49 ± 1.21

2.09 ± 0.95

0.031

1.50 ± 1.39

2.12 ± 1.09

0.001

LDL-C (mmol/L)

3.38 ± 0.37

3.29 ± 0.41

0.571

3.12 ± 0.62

3.36 ± 0.70

0.039

HDL-C (mmol/L)

1.39 ± 0.43

1.24 ± 0.12

0.368

1.30 ± 0.32

1.35 ± 0.37

0.276

AST (U/L)

44.40 ± 7.90

37.30 ± 7.60

0.067

46.30 ± 8.90

38.70 ± 8.70

0.048

ALT (U/L)

43.70 ± 8.90

35.76 ± 9.10

0.039

45.80 ± 10.40

37.80 ± 9.40

0.043

UA (μmol/L)

363.34 ± 81.36

373.43 ± 78.02

0.632

372.51 ± 70.91

367.48 ± 61.32

0.652

 

CRA

Control

Carriers

(n = 7)

Non-carriers

(n = 204)

P value

Carriers

(n = 5)

Non-carriers

(n = 234)

P value

Age (yr)

55.90 ± 0.54

54.90 ± 0.48

0.853

53.80 ± 0.57

54.20 ± 0.65

0.967

BMI (kg/m2)

24.38 ± 1.38

23.85 ± 1.56

0.574

22.98 ± 0.91

23.13 ± 0.77

0.968

CAP (dB/m)

240.66 ± 34.73

227.66 ± 30.67

0.195

210.45 ± 30.67

199.48 ± 25.76

0.698

FPG (mmol/L)

5.04 ± 0.45

4.79 ± 0.71

0.837

4.99 ± 1.03

4.69 ± 0.68

0.753

TC (mmol/L)

5.29 ± 0.98

5.54 ± 0.63

0.111

5.27 ± 0.76

5.74 ± 0.64

0.386

TG (mmol/L)

1.76 ± 1.28

1.92 ± 1.37

0.093

1.36 ± 0.98

1.57 ± 1.21

0.215

LDL-C (mmol/L)

3.23 ± 0.75

3.30 ± 0.63

0.265

2.92 ± 0.97

3.31 ± 0.67

0.470

HDL-C (mmol/L)

1.47 ± 0.63

1.33 ± 0.59

0.097

1.57 ± 0.31

1.31 ± 0.54

0.865

AST (U/L)

36.90 ± 10.80

33.50 ± 7.50

0.683

30.60 ± 6.30

32.70 ± 7.70

0.461

ALT (U/L)

30.60 ± 9.90

32.80 ± 13.10

0.473

26.90 ± 8.10

32.90 ± 10.30

0.643

UA (μmol/L)

358.61 ± 81.53

379.61 ± 84.98

0.352

335.36 ± 67.69

351.55 ± 73.64

0.198

  1. Abbreviations: NAFLD non-alcoholic fatty liver disease, CRA colorectal adenoma, BMI body mass index, CAP controlled attenuation parameter, FPG fasting plasma glucose, TC total cholesterol, TG triglyceride, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, AST aspartate aminotransferase, ALT alanine aminotransferase, UA uric acid
  2. aValues are expressed as mean ± SD and compared by Student’s t-test
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BMC Biochemistry

ISSN: 1471-2091

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