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Table 5 Clinical characteristics of TM6SF2 rs58542926 T carriers and non-carriers in each groupa

From: Association of TM6SF2 rs58542926 gene polymorphism with the risk of non-alcoholic fatty liver disease and colorectal adenoma in Chinese Han population

  NAFLD NAFLD&CRA
Carriers
(n = 13)
Non-carriers
(n = 188)
P value Carriers
(n = 13)
Non-carriers
(n = 175)
P value
Age (yr) 53.80 ± 0.46 55.00 ± 0.51 0.534 54.90 ± 0.61 54.30 ± 0.49 0.411
BMI (kg/m2) 24.99 ± 1.36 23.95 ± 1.23 0.957 24.98 ± 1.98 26.12 ± 2.02 0.053
CAP (dB/m) 262.34 ± 32.65 239.11 ± 37.76 0.031 260.21 ± 22.52 240.46 ± 21.34 0.001
FPG (mmol/L) 4.89 ± 0.98 5.13 ± 0.12 0.163 5.21 ± 0.32 5.26 ± 0.79 0.341
TC (mmol/L) 5.01 ± 0.67 5.63 ± 0.83 0.352 4.80 ± 0.98 5.61 ± 0.78 0.013
TG (mmol/L) 1.49 ± 1.21 2.09 ± 0.95 0.031 1.50 ± 1.39 2.12 ± 1.09 0.001
LDL-C (mmol/L) 3.38 ± 0.37 3.29 ± 0.41 0.571 3.12 ± 0.62 3.36 ± 0.70 0.039
HDL-C (mmol/L) 1.39 ± 0.43 1.24 ± 0.12 0.368 1.30 ± 0.32 1.35 ± 0.37 0.276
AST (U/L) 44.40 ± 7.90 37.30 ± 7.60 0.067 46.30 ± 8.90 38.70 ± 8.70 0.048
ALT (U/L) 43.70 ± 8.90 35.76 ± 9.10 0.039 45.80 ± 10.40 37.80 ± 9.40 0.043
UA (μmol/L) 363.34 ± 81.36 373.43 ± 78.02 0.632 372.51 ± 70.91 367.48 ± 61.32 0.652
  CRA Control
Carriers
(n = 7)
Non-carriers
(n = 204)
P value Carriers
(n = 5)
Non-carriers
(n = 234)
P value
Age (yr) 55.90 ± 0.54 54.90 ± 0.48 0.853 53.80 ± 0.57 54.20 ± 0.65 0.967
BMI (kg/m2) 24.38 ± 1.38 23.85 ± 1.56 0.574 22.98 ± 0.91 23.13 ± 0.77 0.968
CAP (dB/m) 240.66 ± 34.73 227.66 ± 30.67 0.195 210.45 ± 30.67 199.48 ± 25.76 0.698
FPG (mmol/L) 5.04 ± 0.45 4.79 ± 0.71 0.837 4.99 ± 1.03 4.69 ± 0.68 0.753
TC (mmol/L) 5.29 ± 0.98 5.54 ± 0.63 0.111 5.27 ± 0.76 5.74 ± 0.64 0.386
TG (mmol/L) 1.76 ± 1.28 1.92 ± 1.37 0.093 1.36 ± 0.98 1.57 ± 1.21 0.215
LDL-C (mmol/L) 3.23 ± 0.75 3.30 ± 0.63 0.265 2.92 ± 0.97 3.31 ± 0.67 0.470
HDL-C (mmol/L) 1.47 ± 0.63 1.33 ± 0.59 0.097 1.57 ± 0.31 1.31 ± 0.54 0.865
AST (U/L) 36.90 ± 10.80 33.50 ± 7.50 0.683 30.60 ± 6.30 32.70 ± 7.70 0.461
ALT (U/L) 30.60 ± 9.90 32.80 ± 13.10 0.473 26.90 ± 8.10 32.90 ± 10.30 0.643
UA (μmol/L) 358.61 ± 81.53 379.61 ± 84.98 0.352 335.36 ± 67.69 351.55 ± 73.64 0.198
  1. Abbreviations: NAFLD non-alcoholic fatty liver disease, CRA colorectal adenoma, BMI body mass index, CAP controlled attenuation parameter, FPG fasting plasma glucose, TC total cholesterol, TG triglyceride, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, AST aspartate aminotransferase, ALT alanine aminotransferase, UA uric acid
  2. aValues are expressed as mean ± SD and compared by Student’s t-test