Figure 4

The GAS1 family sequence alignment. A) The sequences start from the beginning of the mature human GAS1 and numbered according to the human amino acid numbering. Residues over ca. 85% conserved (11/13) are coloured with a black-to-grey scale, in higher vertebrates (mammals) there is an extended loop in the N-terminal domain around residues 80–100 (human GAS1 numbering). The C-termini are poorly conserved (residues beyond 250), note the RGD sequence at 306–308. B) Conserved surface features on GAS1 displayed on the N-terminal domain. C) Conserved surface features on GAS1 displayed on the C-terminal domain; conserved sites in B and C are coloured in red (with >75% sequence similarity, see text).