Mitochondrial oxidative phosphorylation in autosomal dominant optic atrophy

BMC Biochemistry

Table 3 Specific enzyme analysis of ADOA patient and control mitochondria

	Mean specific enzyme activities nmol/min/mg mitochondrial protein
	Complex I	Complex III	Complex IV	CS ^a
^aOPA1+ (n = 6)
P2	82	1076	884	1410
P3	274	976	568	2074
P4	294	928	1005	1693
P6	86	1313	970	918
P7	52	1078	974	846
P8	122	845	828	1018
Mean ± SD	152 ± 105	1036 ± 162	872 ± 162	1327 ± 488
^aOPA1- (n = 10)
Mean ± SD	190 ± 144	945 ± 174	810 ± 204	1154 ± 650
Control (n = 10)
Mean ± SD	170 ± 64	886 ± 179	893 ± 271	1304 ± 364

^aAbbreviations used above are CS, citrate synthase, OPA1+, OPA1-positive patients, and OPA1-, OPA1-negative patients

ISSN: 1471-2091