Table 1 Viral products manipulate the ubiquitin system in AIDS-related cancers. Summarized here is recent information on the relations between tumor viruses and host cell systems. The general strategy through which the ubiquitin system is manipulated, the effector proteins and the host target proteins are indicated for KSHV, EBV and HPV.
From: Role of the ubiquitin system and tumor viruses in AIDS-related cancer
Malignancies | Kaposi's sarcoma (KSHV) | Immunoblastic B-cell lymphomas (EBV) | Cervical cancer (HPV) |
Strategy | Virus-encoded ubiquitin ligases | Dysregulation of host ubiquitin system | Dysregulation of host ubiquitin system |
Viral Effectors | KSHV K3, K5 and RTA | EBV LMP1 | HPV E6 and E7 |
Cellular Targets | MHC class I, IRF7 | β-catenin, PHD/HIFa, IRF7 | p53, pRb |