Table 2 Mouse models genetically modified for proteins involved in muscle wasting
From: Roles and potential therapeutic targets of the ubiquitin proteasome system in muscle wasting
Genetically modified mice | Effect on muscle (muscle wasting condition tested) | Selected references |
|---|---|---|
KO MuRF-1 | Partial protection against atrophy (denervation) | [31] |
KO Atrogin-1/MAFbx | Partial protection against atrophy (denervation) | [31] |
KO E2-14K | Non-resistant to atrophy (fasting) | [74,114] |
KO UBR1 | Decreased muscle mass | [75] |
Mdx | Model for Duchenne muscular dystrophy: in these mice blockade of NFκB partially restores muscle function | [115] |
KI FoxO | FoxO overexpressing mice: negative effect on skeletal muscle mass | [116] |
MIKK constitutively active IKK | Severe atrophy resembling cachexia | [48] |
MISR non-degradable IκB | Protection against atrophy (denervation, tumor) | [48] |