substrate | KsdATP | KsATP | KsdTTP | KsdGTP | KidATP | KiATP | KaATP | k2 | k2dA | k2A | k2e | k4 | k6 |
---|
ADP | 2 | 200 | 2.4b | 0.5 | 1.25 | 300 | 2000d | 0.21 | Â | Â | Â | 0.03 | 0.16 |
GDP | 1 | 100 | 0.5 | 2 | 2 | 190 | 2400 | 0.28a | Â | Â | Â | 0.04 | 0.19 |
CDP | 2 | 70 | 1.55b | 2c | 1.5 | 600 | 1400 | Â | 0.25a | 0.29a | 0.08 | Â | 0.32 |
UDP | 1 | 100 | 0.7b | 2c | 0.5 | 200 | 800 | Â | 0.26 | 0.26 | Â | Â | 0.26a |
- Binding constants in μM, rate constants in 1/s.
- afixed values taken directly from table 5 of [5].
- busing Eq. 10, these were adjusted to yield fluxes of 12.5, 12.5, 20 and 5 (uM/min) for ADP, GDP, CDP and UDP, respectively, under assumptions of E0 = 16 μM, ADP = 430 μM, GDP = 110 μM, CDP = 55 μM, UDP = 170 μM, KmADP = 12 μM, KmGDP = 4.9 μM, KmCDP = 2 μM, KmUDP = 6.4 μM, ATP = 1450 μM, dATP = 10.5 μM, dGTP = 7.3 μM, dTTP = 30 μM and the remaining parameter values in Table 1, see [7].
- cno data, thus, these can be assumed to have any value between .5 and 2; a default value of 2 was carried down from GDP.
- dno data, 2000 is based on the other rows.