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Table 1 Comparisons of the amino acids potentially involved in dimerization across the Q- and P-axis interface in 3HNR and 17β-HSDcl.

From: Dimerization and enzymatic activity of fungal 17β-hydroxysteroid dehydrogenase from the short-chain dehydrogenase/reductase superfamily

Q-axis interface

P-axis interface

3HNR

17β-HSDcl

3HNR

17β-HSDcl

hydrophobic interactions

hydrophobic interactions

Phe131

Phe120

Phe261

Phe249

Phe135

Phe124

Trp269

Trp257

Phe143

Phe132

salt bridges

Phe144

Phe133

Asp266-Arg52

 

Phe188

Phe177

Asp278-Lys273

Asp266-Lys26

salt bridges/H-bonds

  

Arg140-Asp132

Arg129-Asp121/Glu117

  

His122-Asp198

His111-Asp187