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Table 1 Biochemicals involved in lipid metabolic pathways

From: Metabolomic profiling reveals a role for CPT1c in neuronal oxidative metabolism

PATHWAY

SUB PATHWAY

BIOCHEMICAL NAME

KEGG

CPT1c KO CPT1c WT

Welch's Two-Samplet-Test

CAS

PUBCHEM

Lipid

Essential fatty acid

linoleate (18:2n6)

C01595

0.93

0.4643

60-33-3;

5280450

linolenate [alpha or gamma; (18:3n3 or 6)]

C06427

1.04

0.4808

  

dihomo-linolenate (20:3n3 or n6)

C03242

0.81

0.0608

 

5312529

eicosapentaenoate (EPA; 20:5n3)

C06428

0.72

0.0236

10-2005-9;10417-94-4;

446284

docosapentaenoate (n3 DPA; 22:5n3)

C16513

0.80

0.0662

2234-74-4;

 

docosapentaenoate (n6 DPA; 22:5n6)

C06429

0.77

0.3030

25182-74-5;

6441454

docosahexaenoate (DHA; 22:6n3)

C06429

0.89

0.2879

6217-54-5;

445580

Medium chain fatty acid

caproate (6:0)

C01585

0.98

0.5408

142-62-1;

8892

caprylate (8:0)

C06423

0.99

0.9309

124-07-2;

379

pelargonate (9:0)

C01601

0.89

0.1531

112-05-0;

5461016

laurate (12:0)

C02679

1.01

0.9051

143-07-7;

3893

Long chain fatty acid

myristate (14:0)

C06424

0.99

0.8942

544-63-8;

11005

myristoleate (14:1n5)

C08322

1.26

0.1786

544-64-9;

5281119

palmitate (16:0)

C00249

0.85

0.0781

57-10-3;

985

palmitoleate (16:1n7)

C08362

0.93

0.3794

373-49-9;

445638

margarate (17:0)

 

0.86

0.2288

506-12-7;

10465

10-heptadecenoate (17:1n7)

 

0.81

0.1051

29743-97-3;

5312435

stearate (18:0)

C01530

0.94

0.4536

57-11-4;

5281

oleate (18:1n9)

C00712

0.88

0.2434

112-80-1;

445639

10-nonadecenoate (19:1n9)

 

0.72

0.0470

73033-09-7;

5312513

eicosenoate (20:1n9 or 11)

 

0.78

0.1453

  

dihomo-linoleate (20:2n6)

C16525

0.75

0.0804

2091-39-6;

6439848

arachidonate (20:4n6)

C00219

0.94

0.4832

506-32-1;

444899

docosadienoate (22:2n6)

C16533

0.84

0.3185

7370-49-2;

5282807

adrenate (22:4n6)

C16527

0.81

0.1467

2091-25-0;

5282844

Fatty acid, ester

n-Butyl Oleate

 

0.96

0.7046

142-77-8;

5354342

Fatty acid, dicarboxylate

2-hydroxyglutarate

C02630

1.00

0.8616

40951-21-1;

43

Fatty acid, amide

oleamide

 

1.22

0.7962

301-02-0;

5283387

stearamide

C13846

1.19

0.6546

124-26-5;

31292

Eicosanoid

prostaglandin D2

C00696

1.20

0.1092

41598-07-6;

448457

prostaglandin E2

C00584

0.93

0.3928

363-24-6;

5280360

5-HETE

 

0.99

0.8472

73307-52-5;

9862886

15-HETE

C04742

0.83

0.9669

54845-95-3;

5280724

Endocannabinoid

palmitoyl ethanolamide

 

0.64

0.0331

 

4671

Fatty acid & BCAA metabolism

propionylcarnitine

C03017

1.08

0.4494

17298-37-2;

107738

Carnitine metabolism

carnitine

C00487

0.88

0.0084

461-05-2;

288

3-dehydrocarnitine*

C02636

1.22

0.0103

10457-99-5;

6991982

acetylcarnitine

C02571

0.89

0.2172

5080-50-2;

7045767

oleoylcarnitine

 

0.83

0.3694

  

Fatty alcohol, long chain

1-octadecanol

D01924

1.01

0.8513

112-92-5;

8221

Glycerolipid metabolism

choline phosphate

C00588

0.97

0.4914

72556-74-2;

1014

ethanolamine

C00189

1.10

0.4703

141-43-5;

 

phosphoethanolamine

C00346

1.06

0.5812

1071-23-4;

52,323,241,015

glycerol

C00116

0.97

0.6203

56-81-5;

753

glycerol 3-phosphate (G3P)

C00093

0.98

0.6926

29849-82-9;

754

glycerophosphorylcholine (GPC)

C00670

0.96

0.9071

28319-77-9;

657272

cytidine 5'-diphosphocholine

C00307

1.25

0.0583

33818-15-4;

13805

Inositol metabolism

myo-inositol

C00137

0.94

0.0882

87-89-8;

 

chiro-inositol

 

0.77

0.1568

643-12-9;

 

inositol 1-phosphate (I1P)

 

1.01

0.8432

106032-59-1;

 

scyllo-inositol

C06153

0.90

0.1635

488-59-5;

 

Ketone bodies

3-hydroxybutyrate (BHBA)

C01089

1.23

0.2197

625-72-9;

441

Lysolipid

1-palmitoylglycerophosphoethanolamine

 

1.12

0.8591

 

9547069

2-palmitoylglycerophosphoethanolamine*

 

0.83

0.1926

  

1-stearoylglycerophosphoethanolamine

 

1.20

0.7882

69747-55-3;

9547068

1-oleoylglycerophosphoethanolamine

 

1.14

0.8654

 

9547071

2-oleoylglycerophosphoethanolamine*

 

1.07

0.9602

  

1-arachidonoylglycerophosphoethanolamine*

 

1.06

0.8488

  

2-arachidonoylglycerophosphoethanolamine*

 

0.45

0.2213

  

2-docosahexaenoylglycerophosphoethanolamine*

 

0.48

0.3141

  

1-palmitoylglycerophosphocholine

 

0.47

0.1450

17364-16-8;

86554

2-palmitoylglycerophosphocholine*

 

0.59

0.2106

  

1-stearoylglycerophosphocholine

 

0.51

0.1452

19420-57-6;

497299

2-stearoylglycerophosphocholine*

 

1.00

  

10208382

1-oleoylglycerophosphocholine

 

0.56

0.1923

19420-56-5;

16081932

2-oleoylglycerophosphocholine*

 

0.65

0.3441

  

1-arachidonoylglycerophosphocholine*

C05208

1.00

   

2-arachidonoylglycerophosphocholine*

 

0.89

0.4485

  

1-docosahexaenoylglycerophosphocholine*

 

1.00

   

2-docosahexaenoylglycerophosphocholine*

 

0.86

0.4614

  

1-palmitoylglycerophosphoinositol*

 

0.85

0.2160

  

1-stearoylglycerophosphoinositol

 

0.77

0.1315

  

1-arachidonoylglycerophosphoinositol*

 

0.87

0.3521

  

1-oleoylglycerophosphoserine

 

0.92

0.6515

 

9547099

2-oleoylglycerophosphoserine*

 

0.80

0.1921

  

1-palmitoylplasmenylethanolamine*

 

1.23

0.5225

  

Monoacylglycerol

1-palmitoylglycerol (1-monopalmitin)

 

0.83

0.1685

542-44-9;

14900

1-stearoylglycerol (1-monostearin)

D01947

0.92

0.3625

123-94-4;

24699

2-stearoylglycerol (2-monostearin)

 

0.75

0.1774

621-61-4;

79075

1-oleoylglycerol (1-monoolein)

 

0.80

0.1139

111-03-5;

5283468

2-oleoylglycerol (2-monoolein)

 

0.59

0.0769

3443-84-3;

5319879

Sphingolipid

sphingosine

C00319

0.71

0.3009

123-78-4;

5353955

palmitoyl sphingomyelin

 

0.84

0.1297

 

9939941

stearoyl sphingomyelin

C00550

1.07

0.2147

85187-10-6;85187-10-6;

6453725

Mevalonate metabolism

3-hydroxy-3-methylglutarate

C03761

1.07

0.4426

503-49-1;

5459993

Sterol/Steroid

cholesterol

C00187

1.00

0.9987

57-88-5;

6432564

7-alpha-hydroxycholesterol

C03594

1.24

0.2998

566-27-8;

107722

7-beta-hydroxycholesterol

C03594

1.11

0.2969

566-27-8;

473141

24(S)-hydroxycholesterol

C13550

0.94

0.5728

2140-46-7;

 

corticosterone

C02140

0.59

0.2402

50-22-6;

5753

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BMC Biochemistry

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