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Figure 4 | BMC Biochemistry

Figure 4

From: The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species

Figure 4

Structure-activity for human and mouse VDR. Structure-activity data for bile acid activation of human and mouse VDRs. The bile acids that activate human and mouse VDRs are small, hydrophobic bile acids that are related to lithocholic acid (LCA) and have either a hydroxyl or oxo group at C-3 (LCA, 3-oxo-LCA, LCA acetate, iso-LCA) or have unsubstituted steroid ring (5α-cholanic acid). Addition of a 7α-hydroxy group to LCA (resulting in the bile acid CDCA) or even single steroid ring substitutions at C-7 or C-12 result in bile acids that do not activate the VDRs. Nor-LCA, which has a shortened bile acid side-chain, is also inactive.

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BMC Biochemistry

ISSN: 1471-2091

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