Figure 3

Multiple sequence alignment of the Gg NEU3 repeat units and of the NEU3 variable length region in different species. (A) Multiple sequence alignment of the 7 Gg NEU3 repeat units (Rep1-7). The positional information content according to the Logo analysis is shown at the bottom of the alignment. (B) Multiple sequence alignment of the NEU3 variable length region from different vertebrates located between the highly conserved GCQGSV(L/V/I)SF and WLLY motifs. NEU3 polypeptide sequences from Homo sapiens (Hs), Bos taurus (Bt), Mus musculus (Mm), Taeniopygia guttata (Tg), Danio rerio (Dr) and Hs NEU2 were aligned. The 188 amino acid-long sequence of Gg NEU3 containing the tandem repeats is located in this region but is not shown in the alignment due to its length. The alignments have been carried out using ClustalW2.