Figure 4

Alternative models for helical repeats in the SAPS domain of PP6R3. Line 1. PP6R3 primary sequence, residues 1-513. Positions of the mutations tested in Fig. 6 are highlighted in green. Lines 2-6. 3D-jury models based on: line 2- importin α; line 3- β-catenin; line 4- importin β; line 5- p115. Convex surface helices are red and concave helices are blue cylinders. Lines 7-9 are REP low confidence predictions of: line 7- HEAT; line 8- ARM; line 9- ANK repeats. For consistency with the models we have highlighted these areas pink for convex and light blue concave surfaces. Proposed helical repeat regions are boxed and labelled 1-9. We are less confident in repeats 6-9, labelled grey, compared to repeats 1-5 labeled in black.