Protein and enzyme biochemistry

Section edited by Joel Weiner

Protein and enzyme biochemistry: This section incorporates all aspects of protein and enzyme biochemistry including but not limited to: protein chemistry and proteomics, protein folding and enzyme activity. Applications of these areas, such as in bionanotechnology and biosensors are also welcome.

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  1. Research article

    Identification of replication-dependent and replication-independent linker histone complexes: Tpr specifically promotes replication-dependent linker histone stability

    There are 11 variants of linker histone H1 in mammalian cells. Beyond their shared abilities to stabilize and condense chromatin, the H1 variants have been found to have non-redundant functions, the mechanisms...

    Pei Zhang, Owen E. Branson, Michael A. Freitas and Mark R. Parthun

    BMC Biochemistry 2016 17:18

    Published on: 1 October 2016

  2. Research article

    Effect of mutations to amino acid A301 and F361 in thermostability and catalytic activity of the β-galactosidase from Bacillus subtilis VTCC-DVN-12-01

    Beta-galactosidase (EC 3.2.1.23), a commercially important enzyme, catalyses the hydrolysis of β-1,3- and β-1,4-galactosyl bonds of polymer or oligosaccharidesas well as transglycosylation of β-galactopyranosi...

    Thao Thi Nguyen, Hanh Van Vu, Nhung Thi Hong Nguyen, Tuyen Thi Do and Thanh Sy Le Nguyen

    BMC Biochemistry 2016 17:15

    Published on: 8 July 2016

  3. Research article

    Auto-thiophosphorylation activity of Src tyrosine kinase

    Intermolecular autophosphorylation at Tyr416 is a conserved mechanism of activation among the members of the Src family of nonreceptor tyrosine kinases. Like several other tyrosine kinases, Src can catalyze th...

    M. Zulema Cabail, Emily I. Chen, Antonius Koller and W. Todd Miller

    BMC Biochemistry 2016 17:13

    Published on: 7 July 2016

  4. Research article

    Molecular characterization of protein kinase C delta (PKCδ)-Smac interactions

    Protein kinase C δ (PKCδ) is known to be an important regulator of apoptosis, having mainly pro- but also anti-apoptotic effects depending on context. In a previous study, we found that PKCδ interacts with the...

    Christian Holmgren, Louise Cornmark, Gry Kalstad Lønne, Katarzyna Chmielarska Masoumi and Christer Larsson

    BMC Biochemistry 2016 17:11

    Published on: 23 May 2016

  5. Research article

    1,2-Dichlorobenzene affects the formation of the phosphoenzyme stage during the catalytic cycle of the Ca2+-ATPase from sarcoplasmic reticulum

    1,2-Dichlorobenzene (1,2-DCB) is a benzene-derived molecule with two Cl atoms that is commonly utilized in the synthesis of pesticides. 1,2-DCB can be absorbed by living creatures and its effects on naturally-...

    Javier Vargas-Medrano, Jorge A. Sierra-Fonseca and Luis F. Plenge-Tellechea

    BMC Biochemistry 2016 17:5

    Published on: 11 March 2016

  6. Research article

    Characterization of a cold-active and salt tolerant esterase identified by functional screening of Arctic metagenomic libraries

    The use of metagenomics in enzyme discovery constitutes a powerful approach to access to genomes of unculturable community of microorganisms and isolate novel valuable biocatalysts for use in a wide range of b...

    Concetta De Santi, Bjørn Altermark, Marcin Miroslaw Pierechod, Luca Ambrosino, Donatella de Pascale and Nils-Peder Willassen

    BMC Biochemistry 2016 17:1

    Published on: 19 January 2016

  7. Research article

    A comparison of the enzymatic properties of three recombinant isoforms of thrombolytic and antibacterial protein—Destabilase-Lysozyme from medicinal leech

    Destabilase-Lysozyme (mlDL) is a multifunctional i-type enzyme that has been found in the secretions from the salivary glands of medicinal leeches. mlDL has been shown to exhibit isopeptidase, muramidase and a...

    Alexey S. Kurdyumov, Valentin A. Manuvera, Isolda P. Baskova and Vassili N. Lazarev

    BMC Biochemistry 2015 16:27

    Published on: 21 November 2015

  8. Research article

    The GH5 1,4-β-mannanase from Bifidobacterium animalis subsp. lactis Bl-04 possesses a low-affinity mannan-binding module and highlights the diversity of mannanolytic enzymes

    β-Mannans are abundant and diverse plant structural and storage polysaccharides. Certain human gut microbiota members including health-promoting Bifidobacterium spp. catabolize dietary mannans. Little insight is ...

    Johan Morrill, Evelina Kulcinskaja, Anna Maria Sulewska, Sampo Lahtinen, Henrik Stålbrand, Birte Svensson and Maher Abou Hachem

    BMC Biochemistry 2015 16:26

    Published on: 11 November 2015

  9. Research article

    Evaluating the role of a trypsin inhibitor from soap nut (Sapindus trifoliatus L. Var. Emarginatus) seeds against larval gut proteases, its purification and characterization

    The defensive capacities of plant protease Inhibitors (PI) rely on inhibition of proteases in insect guts or those secreted by microorganisms; and also prevent uncontrolled proteolysis and offer protection aga...

    V D Sirisha Gandreddi, Vijaya Rachel Kappala, Kunal Zaveri and Kiranmayi Patnala

    BMC Biochemistry 2015 16:23

    Published on: 22 October 2015

  10. Research article

    Purification and characterization of a cytochrome c with novel caspase-3 activation activity from the pathogenic fungus Rhizopus arrhizus

    Members of Rhizopus species are the most common cause of mucormycosis, a rare but often fatal fungal infection. Host induced pathogen apoptosis and pathogen induced host cell apoptosis are often involved in funga...

    Manoj Saxena, Rohit Kumar Sharma, Josell Ramirez-Paz, Arthur D. Tinoco and Kai Griebenow

    BMC Biochemistry 2015 16:21

    Published on: 3 September 2015

    The Erratum to this article has been published in BMC Biochemistry 2016 17:3

  11. Research article

    Complex kinetics and residual structure in the thermal unfolding of yeast triosephosphate isomerase

    Saccharomyces cerevisiae triosephosphate isomerase (yTIM) is a dimeric protein that shows noncoincident unfolding and refolding transitions (hysteresis) in temperature scans, a phenome...

    Ariana Labastida-Polito, Georgina Garza-Ramos, Menandro Camarillo-Cadena, Rafael A. Zubillaga and Andrés Hernández-Arana

    BMC Biochemistry 2015 16:20

    Published on: 3 September 2015

  12. Research article

    Identification of inhibitors that target dual-specificity phosphatase 5 provide new insights into the binding requirements for the two phosphate pockets

    Dual-specificity phosphatase-5 (DUSP5) plays a central role in vascular development and disease. We present a p-nitrophenol phosphate (pNPP) based enzymatic assay to screen for inhibitors of the phosphatase domai...

    Terrence S. Neumann, Elise A. Span, Kelsey S. Kalous, Robert Bongard, Adam Gastonguay, Michael A. Lepley, Raman G. Kutty, Jaladhi Nayak, Chris Bohl, Rachel G. Lange, Majher I. Sarker, Marat R. Talipov, Rajendra Rathore, Ramani Ramchandran and Daniel S. Sem

    BMC Biochemistry 2015 16:19

    Published on: 19 August 2015

  13. Research article

    Design of symmetric TIM barrel proteins from first principles

    Computational protein design is a rapidly maturing field within structural biology, with the goal of designing proteins with custom structures and functions. Such proteins could find widespread medical and ind...

    Deepesh Nagarajan, Geeta Deka and Megha Rao

    BMC Biochemistry 2015 16:18

    Published on: 12 August 2015

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