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Table 6 Twenty Top Proteins for Protein-Protein Interaction Network Parameter Terms (network degree, closeness centrality and betweenness centrality). Proteins with a closeness centrality of 1.0 were excluded as they correspond to isolated protein pairs

From: Effect of IAPP on the proteome of cultured Rin-5F cells

Protein Accession # Degree Fold change Protein Accession # Closeness centrality Fold change Protein Accession # Between-ness centrality Fold change
Tpi1 IPI00231767 47 1.8 Gapdh IPI00555252 0.481 0.34 Gapdh IPI00555252 0.135 0.34
Mdh2 IPI00197696 38 0.29 Tpi1 IPI00231767 0.463 1.5 Pcna IPI00200861 0.127 0.89
Sod2 IPI00211593 38 1.1 Alb IPI00191737 0.460 1.3 Actb IPI00189819 0.0683 0.94
Gapdh IPI00555252 37 0.34 Pcna IPI00200861 0.444 0.88 Alb IPI00191737 0.0645 1.3
Cs IPI00206977 35 1.1 Atp5a1 IPI00396910 0.441 1.1 Eef2 IPI00203214 0.0574 1.1
Atp5a1 IPI00396910 34 1.1 Atp5b IPI00551812 0.440 0.44 Atp5a1 IPI00396910 0.0522 1.1
Atp5b IPI00551812 33 0.44 Pgk1 IPI00231426 0.438 0.92 Tpi1 IPI00231767 0.0506 1.5
Pkm2 IPI00231929 31 0.59 Eef2 IPI00203214 0.436 1.1 Cfl1 IPI00327144 0.0387 1.4
Shmt2 IPI00195109 30 1.2 Shmt2 IPI00195109 0.436 1.2 Glud1 IPI00324633 0.0383 2.1
Glud1 IPI00324633 30 2.1 Cs IPI00206977 0.435 1.1 Gnb2l1 IPI00231134 0.0372 1.5
Dld IPI00365545 30 1.9 Pkm2 IPI00231929 0.431 0.59 Gmps IPI00372214 0.0371 120
Alb IPI00191737 29 1.3 Dhfr IPI00200419 0.429 1.2 Rad23b IPI00210495 0.0359 0.96
Pgk1 IPI00231426 27 0.92 Mdh2 IPI00197696 0.424 0.29 Stip1 IPI00213013 0.0343 2.0
Pcna IPI00200861 25 0.88 Actb IPI00189819 0.423 0.94 Mdh2 IPI00197696 0.0332 0.29
Gmps IPI00372214 25 120 Hspa4 IPI00387868 0.423 0.27 Tubb5 IPI00197579 0.0317 0.15
Eef2 IPI00203214 24 1.1 Sod2 IPI00211593 0.422 1.1 Shmt2 IPI00195109 0.0303 1.2
Mdh1 IPI00198717 24 6.0 Gmps IPI00372214 0.419 120 Eif5a IPI00211216 0.0286 0.34
Gnb2l1 IPI00231134 23 1.5 Gnb2|1 IPI00231134 0.413 1.5 Dars IPI00206224 0.0257 1.1
Sod1 IPI00231643 23 0.52 Txn1 IPI00216298 0.411 29 Aprt IPI00950965 0.0256 0.016
Txn1 IPI00231368 23 29 Sod1 IPI00231643 0.409 0.52 Ywhaz IPI00324893 0.0250 0.56