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Table 2 Significantly Down-Regulated Proteins in IAPP Treated Rin-5F Cells. The data were obtained from three independent experiments. To obtain the protein abundance ratio the amount of each protein in the IAPP treated cells was divided by its corresponding amount in the control cells (IAPP untreated cells). The corresponding ratios of all proteins were then averaged between the three experiments. If a specific protein was expressed in either untreated or IAPP treated samples, the missing value was replaced by the smallest amount that was potentially detected by the machine (0.1 femtomole). Differences between IAPP treated and un-treated expression levels are considered to be significant if p ≤ 0.05. To determine the p value two-tailed Student’s t-test was performed, comparing the three individual control amounts with the three corresponding treated samples

From: Effect of IAPP on the proteome of cultured Rin-5F cells

Accession # UniProt Id Description Mean ratio (IAPP treated/control) SD p Value
IPI00471525 Q68FR9/F1LP72 Uncharacterized protein 0.054 0.076 0.048
IPI00231968 Q5U362 Annexin A4 isoform CRA a 0.097 0.059 0.043
IPI00210357 Q794E4 Heterogeneous nuclear ribonucleoprotein F 0.126 0.040 0.048
IPI00470288 Q9EQS0/P07335 Creatine kinase B type 0.143 0.027 < 0.001
IPI00208215 Q9Z0V6 Thioredoxin dependent peroxide reductase mitochondrial 0.221 0.009 0.034
IPI00387868 O88600/F1LRV4 Heat shock 70 kDa protein 4 0.273 0.021 0.048
IPI00211779 Q63716 Peroxiredoxin 1 0.277 0.001 0.032
IPI00197696 Q0QF43/P04636 Malate dehydrogenase mitochondrial 0.291 0.104 0.013
IPI00201333 D4A0W9 Uncharacterized protein 0.388 0.139 0.050
IPI00190559 Q9EQX9 Ubiquitin conjugating enzyme E2 N 0.453 0.100 0.021
IPI00324893 P63102 14 3 3 protein zeta delta 0.558 0.088 0.001
IPI00200147 P19945 60S acidic ribosomal protein P0 0.678 0.057 0.043
IPI00365935 P83868/B2GV92 Prostaglandin E synthase 3 0.692 0.070 0.005
IPI00200861 P04961 Proliferating cell nuclear antigen 0.877 0.315 0.005
IPI00189925 P54921 Alpha soluble NSF attachment protein 0.005 1.865 0.038
IPI00189989 B2RYK3/P18297 Sepiapterin reductase 0.006 1.089 0.027
IPI00363925 B5DEH4 Uap1l1 protein 0.014 0.234 0.015
IPI00365423 O35511/Q5XI34 Protein phosphatase 2 Formerly 2A regulatory subunit A alpha isoform 0.003 4.101 0.050
IPI00370456 Q4FZT9 26S proteasome non ATPase regulatory subunit 2 0.007 0.491 0.016
IPI00768299 B2GV73/F1LRL8 Actin related protein 2 3 complex subunit 3 Predicted isoform CRA b 0.010 0.798 0.037