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Fig. 9 | BMC Biochemistry

Fig. 9

From: Structural similarities and functional differences clarify evolutionary relationships between tRNA healing enzymes and the myelin enzyme CNPase

Fig. 9

Domain arrangement of PNK/CPDase proteins. a Multiple sequence alignment using T-Coffee [54]. Aligned sequences of ScTrl1 PNK/CPDase (Sc), BfPNK/CPDase (Bf), MmCNPase (mouse), and HsCNPase (human). The N-terminal P-loop motif and two C-terminal H-x-(T/S)-x motifs are underlined in red and green, respectively. b Superposition of the homology model of the CPDase domain of BfPNK/CPDase (blue), generated using Phyre 2, and the crystal structure of the catalytic domain of MmCNPase (yellow) [PDB ID: 2YDB] [27, 53]. The black arrows point to the locations of flexible loops in the homology model of the CPDase domain of BfPNK/CPDase (blue). c The overall three-dimensional shapes of PNK/CPDase proteins determined in this study can be used to propose a structural arrangement of the domains

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BMC Biochemistry

ISSN: 1471-2091

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