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Table 1 DUSP5 PD(WT) inhibitor IC50 values with time

From: Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor

 

Assay Reaction Period

Inhibitor Compounds

0 – 10 min

15 – 25 min

30 – 40 min

MP Biomedicals

32.5 ± 2.8

5.9 ± 0.2

3.3 ± 0.2

 RR535

86.6 ± 8.0

16.5 ± 0.7

6.3 ± 0.2

 RR601

36.9 ± 3.9

36.5 ± 1.5

34.5 ± 1.4

  1. IC50 values (± SE) for MP Biomedicals, RR535, and RR601 were determined in the presence of DUSP5 PD(WT) as described in Fig. 4. Data was collected during three successive 10 min assays with pNPP as the substrate
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BMC Biochemistry

ISSN: 1471-2091

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