Fig. 2
Adducts bound to the outer cavity of the LdtMt2 catalytic site. a Overlay of the LdtMt2-biapenem (enzyme carbon atoms colored in blue) and LdtMt2-tebipenem (in orange) catalytic sites as viewed from the outer cavity. The protein residues that interact with the MTOA adducts are shown and common hydrogen bond interactions indicated as cyan dashed lines. b Similar view of the catalytic site of the tebipenem complex crystal structure showing a portion of the solvent accessible surface of the outer cavity and tunnel connecting to the inner cavity, displaying the adduct and residues of the Ldt motif participating in the interaction with the it. The MTOA adduct is colored green