Table 1 Unique residues in class V ADH
From: Computational studies of human class V alcohol dehydrogenase - the odd sibling
Residue | Protein localization | Prevalence class V | Prevalence other classes | Residues in other classes |
|---|---|---|---|---|
Glu49 | Active site | >80 % | <1 % | Asp in other classes (>95 %). |
Met50 | Active site | >70 % | 0 % | Asp in class I and IV (>85 %), Ala in class II and III (>95 %), Asp or Asn in class VI (>70 %). |
Lys51 | Active site | 100 % | 0 % | His in class I and IV (>90 %), His or Thr in class II, Tyr in class III (>99 %), His in class VI (100 %) |
Gly141 | Active site | >55 % | 0 % | Leu in class I (>65 %), Met in class II (>55 %), Met in class III (>95 %), Met in class IV (>80 %), Phe in class VI (>65 %) |
Phe255a | Surface | >75 % | 0 % | Lys in class I (>60 %), Ile in class II and III (>60 %), Ser in class IV (>90 %), Met or Val in class VI (>65 %) |
Arg265 | In central β-sheet | >75 % | 0 % | Ser in class I and III (>95 %), Ala in class II (>80 %), Thr in class IV (>75 %), Ala in class VI (>90 %) |
Leu295 | Dimer interaction | >55 % | 0 % | Pro in class I (>90 %), Ala in class II (>45 %), Ala in class III (>90 %), Pro in class IV (100 %), Ala in class VI (>80 %) |
Val299 | Dimer interaction | >55 % | 0 % | Gln in class I (>90 %), Lys in class II (>50 %), Glu in class III (>90 %), Lys in class IV (>90 %), Ser in class VI (>65 %) |
Gly305 | Dimer interaction | >80 % | 0 % | Pro in others (class I >99 %, class II >65 %, class III >95 %, class IV > 95 %), Ala or Pro in class VI (>98 %) |
Val359 | Near active site | >80 % | 0 % | Phe in others (class I >99 %, class II >75 %, class III >95 %, class IV >95 %, class VI >70 %) |