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Table 1 Constituents of the pathway profiling database. The types of cellular signals for the reporter gene assays and cell lines of the proliferation assays are shown

From: Tubulin is a molecular target of the Wnt-activating chemical probe

Cellular reporter gene assays

Cellular proliferation assays

cAMP response element (CRE) signal

HEK293T

Nuclear factor of activated T-cells (NFAT) signal

MRC5 (high density)

Nuclear factor kappa- light-chain-enhancer of activated B cells (NF-kB) signal

MRC5 (low density)

Serum response element (SRE) signal

A549

Serum response factor (SRF) signal

PC3

p53 signal

LNCaP

E2F signal

Jurkat

Activating transcription factor 6 signal

MDA-MB-231

Hedgehog signal

 

Hypoxia-inducible factor 1 (HIF1) signal

 

Nuclear factor erythroid 2-related factor 2 (Nrf2) signal

 

SMAD signal

 

Wnt signal

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