Fig. 4From: Conserved motif VIII of murine DNA methyltransferase Dnmt3a is essential for methylation activityBinding curves obtained by titration of the fluorescein labeled unmethylated oligodeoxynucleotide duplex fGC GC/CG CG (10 nM) with increasing amounts of Dnmt3a-CD or its variants in the presence of AdoHcy (0.1Â mM). P represents the polarization value. The lines signify the best fits to the model described in [27]. Enzyme concentration is shown in terms of monomerBack to article page