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Table 1 Structures, Docking Energies, and IC50 Values of DUSP5 PD Inhibitors

From: Identification of inhibitors that target dual-specificity phosphatase 5 provide new insights into the binding requirements for the two phosphate pockets

Chemical structure Docking energy (kcal/mol) IC50 from enzyme assay
SM1842 −9.69 5.1 ± 1.9 mM
−9.69 26 ± 3 mM
RR505
−9.89 16 ± 2 mM
RR506
−8.48 6.4 ± 0.8 mMa
Naphthalene trisulfonate (NTS)
NA 44 ± 6 μMa (K i = 25 ± 5 μM)a
Suramin
  1. aObtained in absence of Triton X-100