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Figure 9 | BMC Biochemistry

Figure 9

From: The exchanged EF-hands in calmodulin and troponin C chimeras impair the Ca2+-induced hydrophobicity and alter the interaction with Orai1: a spectroscopic, thermodynamic and kinetic study

Figure 9

The proposed model of the 1 :2 CaM /Orai -CMBD complex. The coordinates for the proposed model were obtained as a courtesy from Dr. Birnbaumer. One of two peptides (stick model) forms a partial helix structure and is bound in the hydrophobic patch (primarily gray) formed by CaM-N, shown as an electrostatic potential surface, where Trp76 (cyan) is deeply buried. The other Orai-CMBD shown in cartoon model (green) is flanked by the Ca2+-bound (orange) EF-hands in CaM-C.

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