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Figure 6 | BMC Biochemistry

Figure 6

From: Protein expression, characterization and activity comparisons of wild type and mutant DUSP5 proteins

Figure 6

Computational modeling of human pERK2 and DUSP5 proteins. Panels (A and A’) are computational model of human pERK2 with DUSP5 protein complex from different points of view (pERK2 is shown in surface representation). Panel (B) represents the binding interface between EBD and pERK2, which consists of kinase interaction motif (KIM) of EBD and common docking motif (CD) of pERK2, as well as of hydrophobic 59AVSA62 sequence of EBD and hydrophobic groove of pERK2. Panel (C) represents the interaction of activation segment of pERK2 (TPO185-Glu-PTR187) with the active site of DUSP5. Panels (C and D) are schematic representation of the effect of serine-to-proline mutation on the DUSP5/pERK2 complex.

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