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Figure 4 | BMC Biochemistry

Figure 4

From: Phosphorylation in intrinsically disordered regions regulates the activity of Neurogenin2

Figure 4

Annotated1H,15N 2D spectra of phosphorylated15N-mNgn2 showing altered structural positions of phosphorylated residues. (A) Detail of overlayed 2D [1H, 15N] HSQC spectra of 15N mNgn2 phosphorylated with cycA/CDK2. Resonances corresponding to phosphorylated Ser and Thr residues are labelled. (B) Secondary Structure Propensity (SSP, [46]) along the mNgn2 sequence calculated based on the available CA and CB chemical shifts (Additional file 4: Table S1). SSP scores correspond to a calculated percentage of occupancy: the 0.1/-0.1 thresholds, here represented as red lines, being empirically proposed for significance. Regions with positive values are associated with a preferential α-helical conformation, here presented as cylinders. Regions with negative values are associated with a preferential extended conformation, here presented as arrows.

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