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Figure 2 | BMC Biochemistry

Figure 2

From: HPV E6, E6AP and cervical cancer

Figure 2

The X-ray crystal structure of the complex of the E6AP HECT domain with UbcH7 (PDB 1DF5). The HECT N lobe (blue), linker (red) and C lobe (green) are indicated. UbcH7 (magenta) was co-crystallized with the HECT domain, while ubiquitin (black) is modeled into the structure shown based on a Ubc1-ubiquitin model [72] (PDB 1FXT). The dashed line represents the 41 Å line-of-site between the active-site cysteines of UbcH7 and E6AP. Adapted from [38].

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