Figure 1

Structural and functional domains of E6AP and E6. The schematic of E6AP (also known as UBE3A) indicates the location of the E6 binding site (E6 BS) and the catalytic HECT domain. The two zinc binding domains and the C-terminal PDZ binding epitope of HPV16 E6 are indicated. Some of the targets that are inactivated by the E6/E6AP complex are indicated.