Figure 6

Model for release of RGMc from the cell membrane. Membrane-associated heterodimeric RGMc (20/35 kDa) is not found in extracellular fluid [14], and its mechanisms of processing are unknown. Full-length membrane-linked 50 kDa RGMc may be digested by a phospholipase (PI-PLC) or by an uncharacterized protease, and then by a PC to generate the 40 kDa species. Alternatively, a PC may directly cleave 40 kDa RGMc at the membrane. The starbursts represent N-linked glycosylation sites, and the thin lines, disulfide bonds.