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Table 1 Kinetic and inhibitory properties of CA II measured by the stopped-flow method

From: Modification of carbonic anhydrase II with acetaldehyde, the first metabolite of ethanol, leads to decreased enzyme activity

Enzyme

kcat (s-1)

KM (mM)

kcat/KM (M-1s-1)

KI (acetazolamide) (nM)

Native CA II

1.40·106

9.3

1.5·108

12

CA II + AA + NaBH 3 (CN)

0.77·106

9.3

0.5·108

35

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BMC Biochemistry

ISSN: 1471-2091

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