Figure 3

A: Amino acid sequence alignment of the non helical head domain (H) of vimentin from human (Hsa) and mouse (Mmu). Starting points of the truncated vimentin derivatives used in this study are indicated (a = Δ12, b = Δ 20, c = Δ 30, d = Δ 42, e = Δ 50, f = Δ H). The numbers indicate how many amino acids were deleted from the amino-terminus. Phosphorylation sites in the vimentin head domain are indicated as reviewed in [33]. Black dots represent phosphorylation sites on human vimentin as mentioned in [26, 35]. Open circles indicate phosphorylation sites in the mouse vimentin head domain according to [34]. Vimentin phosphorylation sites found in the hamster are symbolized by black squares [21]. B: A hypothetical structural model for the human vimentin head domain. Amino acids are represented by circles or boxes, aromatic amino acids are boxed, basic ones are filled, and potential phosphorylation sites are dotted. Figure modified from [26].