Figure 1From: Molecular evolution of B6 enzymes: Binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzymeIntermediates in protein-assisted PLP-dependent racemization and β-decarboxylation. Only the reactions found to be catalyzed by the RNase-PLP adduct are depicted; not shown are the pathways for transamination, α-decarboxylation, Cα-Cβ cleavage, β/γ-elimination, and β/γ-substitution.Back to article page