Figure 1
From: Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes
A drug binding pocket of sufficient size coincides with p27 Glu185 in the complex of p27, Cks1 and Skp2. Blue ribbon: Skp2. Gold ribbon: Cks1. Green ribbon: p27 peptide. Stick display: pThr187 and Glu185 of p27. Grey/pink geometric object: potential drug binding solvent pocket at Cks1-Skp2 interface seen in the absence of p27, as computed by the method of An et al. [54]. Inset upper left: zoomed in view of the pocket, pThr187 and Glu185 of p27.