From: Roles and potential therapeutic targets of the ubiquitin proteasome system in muscle wasting
Main models of muscle wasting | Variation of key components involved in UPS activation | |||||
---|---|---|---|---|---|---|
 | UPS mRNAs | N-end rule pathway | NFκB activity | MuRF-1 | MAFbx | Selected reference |
Cancer cachexia |
|
|
|
|
| [84,100] |
Sepsis |
|
|
|
|
| [101,102] |
Hindlimb suspension |
|
|
|
|
| [89,103] |
Denervation |
| ? |
|
|
| [17,31,104] |
Hyperthyroidism |
| ? |
|
|
| [17,105] |
Burn injuries |
|
|
|
|
| [106,107] |
Cirrhosis |
| ? |
|
|
| [108,109] |
Starvation |
|
|
|
|
| [110,111] |
Diabetes |
|
|
|
|
| [56,105,112] |
Uremia |
| ? |
|
|
| [37,113] |