The Fanconi anemia pathway and ubiquitin

BMC Biochemistry

Table 1 The responsible genes for Fanconi anemia

Subtype	Responsible gene	Protein (kDa)	Requirement for FANCD2 monoubiquitylation	Function of the protein, etc.	Homologs in
					Yeast	Plant	Fly	Worm	Fish	Amphibian	Human, mouse, chicken
					S. cerevisiae	A. thaliana	D. melanogaster	C. elegans	D. rerio	X. laevis
A	FANCA	163	+	FA core complex					+ [123]	+ [124]	+
B	FANCB	95	+	FA core complex					+ [123]	+ [124]	+
C	FANCC	63	+	FA core complex					+ [123]	+ [124]	+
D1	FANCD1/BRCA2	380	-	RAD51 recruitment				+ [135]	+ [123]	+ [124]	+
D2	FANCD2	155,162	+	monoubiquitylated protein		+ [133]	+ [27,125]	+ [126]	+ [123,127]	+ [124]	+
E	FANCE	60	+	FA core complex					+ [123]	+ [124]	+
F	FANCF	42	+	FA core complex					+ [123]	+ [136]	+
G	FANCG/XRCC9	68	+	FA core complex					+ [123]	+ [124]	+
I	not identified	?	+	?
J	FANCJ/BACH1/BRIP1	130	-	5′→3′ DNA helicase/ATPase	+ [132]			+ [126]			+
L	FANCL/PHF9/POG	43	+	FA core complex, E3 ubiquitin ligase		+ [134]	+ [27,125]		+ [123]	+ [124]	+
M	FANCM/Hef	250	+	FA core complex, ATPase/translocase, DNA helicase motifs	+ [27]		+ [125]	+ [126]			+
N	FANCN/PALB2	130	-	regulation of BRCA2 localization					+	+	+

(Adapted with modifications from “The molecular pathogenesis of Fanconi anemia: recent progress” Taniguchi T and D'Andrea AD. Blood, Jun 2006; 107: 4223–4233. [6])
FANC protein homologs shown in the table are limited to the ones reported in the literature [27,123–127,132–136].

ISSN: 1471-2091