Figure 2

Analysis of K/R rich regions in the FTO family. (A) Plot of the percentage of K/R residues in a window of 17 amino acids of human FTO. The sequence fragment indicated from position 2 to 18 includes the maximum (7/17 at position 10). (B) Representation of the multiple (full) sequence alignment of the FTO family. White indicates regions with more than 30% of K+R residues in a window of 17 amino acids along the aligned sequences and red represents gaps in the alignment. The N-terminal region around the predicted bipartite NLS signal of human FTO stands as the only K/R-rich region conserved in fish as well as mammalian sequences. Both plots were generated using the BiasViz java tool [30].