Figure 6

Comparisons of the primary and secondary structures of rat Ap-B and human LTA ₄ H. Primary structure alignments of rat Ap-B (RnAp-B) and human LTA₄H (HsLTA4H) are compared to secondary structures deduced from the Ap-B model (upper line) and from the LTA₄H crystal structure (lower line; PDB accession number:1HS6; [27]) using Procheck software. Residue accessibility computed using the Procheck software are indicated by a color code (see below). Five hydrophobic patches detected in each protein using the Quilt method are also shown in the primary structure of each enzyme. The color code (from larger to smaller patch; see also results section and Figure 8) is the following: red, green, magenta, cyan and yellow, respectively. Dashes typify gaps. Symbols used in the secondary structure schemes are indicated at the bottom of the figure.