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Table 2 Comparison of rHSulf-2 requirements for mobilization of heparin-bound ligands

From: HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1

Ligand Concentration required for 50% release of heparin-bound ligand
  rHSulf-2 (μg/mL)
VEGF 0.34
FGF-1 0.36
FGF-2 >4.0
CXCL12 (SDF-1) 0.44
CCL21 (SLC) 3.1
CXCL8 (IL-8) 3.4
CXCL10 (IP-10)a 2.0
  1. a Kd for heparin-BSA was 62 nM. The fixed concentration of ligand tested in the assay was 50 nM.