Figure 6
From: Nitric oxide agents impair insulin-mediated signal transduction in rat skeletal muscle
The effects of a NO scavenger, carboxy-PTIO and NO donors on content of IR-β (A), tyrosine phosphorylation (B) and serine phosphorylation (C) in rat skeletal myocytes. Rat skeletal myocytes were treated with the NO-scavenger, carboxy-PTIO (0.1 μM) with 25 mg/ml of GSNO or SNAP in the presence the indicated concentrations of insulin, with or without 25 mg/ml glucose (Glu). Values are expressed as means ± SEM; * p < 0.05 vs the insulin-stimulated control (100 mM insulin).