Figure 4

Alignment of selected mammalian ARD proteins. The top four sequences are Human, Chimp, Mouse and Rat ARD1, respectively. The bottom five are Human, Chimp, Mouse and Rat ARD2, plus the additional Rat ARD whose expression was confirmed. ARD1 exons are shown as alternating shaded and unshaded regions and exon boundaries that split a codon are shown in darker shading. The large boxed region is for the acetyltransferase domain (identified by a match to Pfam domain PF00583). The smaller boxed region at position 117 shows the Ala-Pro substituion in human ARD2. Sequence identifiers are from Ensembl.