Figure 9
From: Stimulation of Myc transactivation by the TATA binding protein in promoter-reporter assays
Synergy between Myc and TBP to activate ODC Luc (see Fig. 8) is diminished by mutations in TBP that inhibits TATA box binding (TATA def), interaction with RNA polymerase II (pol2 def) or interaction with RNA polymerase III (pol3 def). Myc (1 μg) was cotransfected with ODC Luc and 4 μg of wild-type or mutant TBP constructs. Bars are shown as averages with standard deviation (n = 4). Transfections were performed using NIH 3T3 cells.