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Table 2 Comparison of NADP+-dependent isocitrate dehydrogenases from different organisms.

From: Comparison of Mycobacterium tuberculosis isocitrate dehydrogenases (ICD-1 and ICD-2) reveals differences in coenzyme affinity, oligomeric state, pH tolerance and phylogenetic affiliation

Organism

Km(isocitrate)

Km(NADP+)

Blastocladiella emersonii

20 μM

10 μM

Chlorobium limicola

45 μM ± 13

27 μM ± 10

Bacillus substilis

5.9 μM ± 0.9

14.5 μM ± 2.2

Escherichia coli

4.9 μM ± 0.2

19.6 μM ± 3.6

Synechocystis sp PCc 6803

59 μM

12 μM

Pyrococcus furiosus

-

4400 μM

Aeropyrum pernix

-

30 μM

Thermotoga moritima

-

55.2 μM

Aeropyrum fulgidus

-

30 μM

Mycobacterium phlei (ATCC-354)

74 μM

53 μM

M. tb ICD-1

10 μM ± 5

125 μM ± 5

M. tb ICD-2

20 μM ± 1

19.6 μM ± 6

Beef liver NADP+-IDH

1.7 μM

7.3 μM

Rat liver (cytosolic)

9.7 μM ± 2.9

11.5 μM ± 0.2

Porcine heart NADP+ IDH

-

5 μM ± 0.19